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235296

Sigma-Aldrich

2-(Trifluoromethyl)phenylacetic acid

98%

Synonym(s):

(α,α,α-Trifluoro-o-tolyl)acetic acid

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About This Item

Linear Formula:
CF3C6H4CH2CO2H
CAS Number:
3038-48-0
Molecular Weight:
204.15
EC Number:
221-240-4
MDL number:
MFCD00004327
UNSPSC Code:
12352100
PubChem Substance ID:
24854094
NACRES:
NA.22

Assay

98%

form

solid

mp

100-102 °C (lit.)

functional group

carboxylic acid
fluoro

SMILES string

OC(=O)Cc1ccccc1C(F)(F)F

InChI

1S/C9H7F3O2/c10-9(11,12)7-4-2-1-3-6(7)5-8(13)14/h1-4H,5H2,(H,13,14)

InChI key

TYOCDHCKTWANIR-UHFFFAOYSA-N

Related Categories

Application

2-(Trifluoromethyl)phenylacetic acid has been used in the synthesis of potential antithrombotics and lipoxygenase inhibitors.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKBD3916V
MKBD3916
MKBC7618
MKBC5453
71196MJ

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P L Barker et al.
Journal of medicinal chemistry, 35(11), 2040-2048 (1992-05-29)
Stimulation of platelets activates GPIIbIIIa, the heterodimeric integrin receptor, to bind fibrinogen (Fg), which results in platelet aggregation. GPIIbIIIa/Fg binding inhibitors are potentially suitable for acute use during and after thrombolytic therapy as antithrombotic agents. Incorporation of the tripeptide sequence
E S Lazer et al.
Journal of medicinal chemistry, 33(7), 1892-1898 (1990-07-01)
A series of 2,6-disubstituted 4-(2-arylethenyl)phenols with potent human neutrophil 5-lipoxygenase (5-LO) inhibiting activity (IC50S in the 10(-7) M range) and weaker human platelet cyclooxygenase (CO) inhibiting activity (IC50S in the 10(-6) M range) is described. This series evolved from the

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