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197688

Sigma-Aldrich

3-(3,4-Dimethoxyphenyl)-1-propanol

99%

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About This Item

Linear Formula:
(CH3O)2C6H3(CH2)3OH
CAS Number:
3929-47-3
Molecular Weight:
196.24
EC Number:
223-499-9
MDL number:
MFCD00002951
UNSPSC Code:
12352100
PubChem Substance ID:
24851842
NACRES:
NA.22

Quality Level

100

Assay

99%

refractive index

n20/D 1.54 (lit.)

bp

142-144 °C/0.5 mmHg (lit.)

density

1.081 g/mL at 25 °C (lit.)

SMILES string

COc1ccc(CCCO)cc1OC

InChI

1S/C11H16O3/c1-13-10-6-5-9(4-3-7-12)8-11(10)14-2/h5-6,8,12H,3-4,7H2,1-2H3

InChI key

ZISWRXJZUKDIOO-UHFFFAOYSA-N

Application

3-(3,4-Dimethoxyphenyl)-1-propanol was used in the synthesis of fluorinated benzamide neuroleptic, (S)-N-[(1-ethyl-2- pyrrolidinyl)methyl]-5-(3-fluoropropyl)-2,3-dimethoxybenzamide.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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J Mukherjee
International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes, 42(8), 713-721 (1991-01-01)
Synthesis of a fluorinated benzamide neuroleptic, (S)-N-[(1-ethyl-2- pyrrolidinyl)methyl]-5-(3-fluoropropyl)-2,3- dimethoxybenzamide starting from 3-(3,4-dimethoxyphenyl)-1-propanol in 20-25% overall yield is reported. Radiosynthesis of (S)-N-[(1-ethyl-2-pyrrolidinyl)methyl]- 5-(3[18F]fluoropropyl)-2-methoxybenzamide([18F]FPHB) and (S)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(3[18F]fluoropropyl)-2,3- dimethoxybenzamide([18F]FPHB) was carried out by nucleophilic substitution reaction of (S)-N-[(1-ethyl-2-pyrrolidinyl)methyl-5-(3-tosyloxypropyl)-2-me tho xybenzamide and (S)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(3-tosyloxypropyl)-2,3- dimethoxybenzamide respectively

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