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U2875

Sigma-Aldrich

Uric acid sodium salt

Synonym(s):

2,6,8-Trihydroxypurine, Sodium acid urate

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About This Item

Linear Formula:
C5H3N4O3Na
CAS Number:
1198-77-2
Molecular Weight:
190.09
EC Number:
214-838-1
MDL number:
MFCD00067310
UNSPSC Code:
41106305
PubChem Substance ID:
24900636
NACRES:
NA.51
Pricing and availability is not currently available.

biological source

microbial
synthetic

Quality Level

200

Assay

11.0-13.0% anhydrous basis (Sodium, ICP)

form

powder

solubility

1 M NaOH: 25 mg/mL, clear, colorless to faintly yellow

SMILES string

[Na].O=C1NC(=O)C2=C(N1)NC(=O)N2

InChI

1S/C5H4N4O3.Na.H/c10-3-1-2(7-4(11)6-1)8-5(12)9-3;;/h(H4,6,7,8,9,10,11,12);;

InChI key

IHMJZGFANDMEJM-UHFFFAOYSA-N

Related Categories

Application

Uric acid sodium salt has been used in isotonic solution of NaCl dose titration study.[1] It has been used as a suspension in NaCl for intra-articular administration to experimental animals to induce synovitis.[2]

Biochem/physiol Actions

Sodium urate is the sodium salt of uric acid. In gout, it is observed in synovial fluid.[3] Sodium urate has been shown to precipitate calcium oxalate from urine.[4] It is also known to reverse the inhibitory effects of reactive oxygen and nitrogen metabolites on gelatinase A activity.[5] Excess sodium urate in soft tissues results in a condition referred to as tophi.[6]

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCK9956
BCCH3341
BCCF5862
BCCB4889
BCBR7559V

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Jieru Han et al.
Journal of natural medicines, 75(1), 37-47 (2020-08-08)
Monosodium urate (MSU)-mediated inflammation is closely related to gouty arthritis (GA). Dioscin, an active ingredient, has been reported to possess anti-inflammatory property. Nevertheless, the role of dioscin in GA and the underlying mechanism have not been fully understood. In the
Linne & Ringsrud's Clinical Laboratory Science, 429-432 (2015)
Preferential accumulation of meloxicam in inflamed synovial joints of dogs
Johnston L and Narbe R
The Veterinary Record, vetrec-ve2011 (2012)
Medical Biochemistry, 410-410 (2014)
Rocío Cánovas et al.
Lab on a chip, 17(14), 2500-2507 (2017-06-28)
A novel low-cost, compact and sensitive paper-based platform for the accurate monitoring of glucose in biological fluids is presented. Paper-based working and reference electrodes are combined to build a whole potentiometric cell, which also fits a sampling module for simple
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Questions

1–3 of 3 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  3. What's the Grade of this compound?

    1 answer

    1. This is a research grade Uric Acid Sodium Salt.

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