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SML3304

Sigma-Aldrich

TP-040n

≥98% (HPLC)

Synonym(s):

4-(4-Methyl-1-piperazinyl)-N-(2-phenylethyl)-2-pyrimidinamine

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About This Item

Empirical Formula (Hill Notation):
C17H23N5
CAS Number:
1201173-75-2
Molecular Weight:
297.40
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

CN1CCN(C2=CC=NC(NCCC3=CC=CC=C3)=N2)CC1

InChI

1S/C17H23N5/c1-21-11-13-22(14-12-21)16-8-10-19-17(20-16)18-9-7-15-5-3-2-4-6-15/h2-6,8,10H,7,9,11-14H2,1H3,(H,18,19,20)

InChI key

BNXNWRSVYQHTOH-UHFFFAOYSA-N

Biochem/physiol Actions

TP-040n is an inactive control for TP-040 a brain penetrant, potent and selective inhibitor of O-GlcNAcase (OGA).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000173376
0000179525
0000179523

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Michiko Tawada et al.
Journal of medicinal chemistry, 64(2), 1103-1115 (2021-01-07)
O-GlcNAcase (OGA) has received increasing attention as an attractive therapeutic target for tau-mediated neurodegenerative disorders; however, its role in these pathologies remains unclear. Therefore, potent chemical tools with favorable pharmacokinetic profiles are desirable to characterize this enzyme. Herein, we report

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