Product P1867 - Plasmin from human plasma is from an outside supplier and the manufacturing process is considered proprietary. The product is activated with Streptokinase and this enzyme is removed in the final steps of the purification. The product is >95% by SDS PAGE. The product is >3% protein (the exact value will be on the lot specific Certificate of Analysis). This material is lyophilized from 20 mM sodium phosphate (pH 7.4), containing 25 mM Trehalose. The lyophyllization buffer will contribute a significant amount of solids to the product. The product package size is based on protein content.
P1867
Plasmin from human plasma
lyophilized powder, ≥2.0 units/mg protein
Synonym(s):
Fibrinolysin
About This Item
Recommended Products
form
lyophilized powder
Quality Level
specific activity
≥2.0 units/mg protein
impurities
HIV, Hepatitis B and Hepatitis C, tested negative
UniProt accession no.
application(s)
diagnostic assay manufacturing
storage temp.
−20°C
Gene Information
human ... PLG(5340)
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General description
Application
Biochem/physiol Actions
pH Optimum: 8.5
pH 7.5: ~40% of maximal activity, pH 9.5: ~50% of maximal activity
Temperature Optimum: 37 °C with rapid inactivation at 56 °C
Packaging
Unit Definition
Physical form
Disclaimer
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Can you provide a method of production for Product P1867 - Plasmin?
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Is more information available on the solubility of product P1867 to aid with its application?
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The solubility of this product is not part of the QC testing; however, according to literature data, it should dissolve at least up to 1 mg/ml in an aqueous solvent. This preparation is recommended to go into water.
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Is the P1867-150UG product in Lys-Plasmin form or Glu-Plasmin form?
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Both the Glu- and Lys- forms are assumed to be present in the product, as amino-terminal peptides are released from the native Glu-form to the new Lys-form by plasmin in vivo and during purification. No separation of the two forms is performed once purified plasminogen has been converted to plasmin.
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What is Product P1867, Plasmin from human plasma, soluble in?
1 answer-
It is soluble in water.
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Does Product P1867, Plasmin from human plasma, have a recommended retest date?
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If a product has a recommended retest date this would be on the Certificate of Analysis found at our website. If no recommended retest date is found on the Certificate of Analysis, then the guarantee of quality is one year from the time of delivery for unopened bottles stored at the recommended temperature.
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Can Product P1867, Plasmin from human plasma, be stored?
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Sigma has not evaluated the solution stability of plasmin solutions.It is best to prepare solutions fresh.
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What is the molecular weight of Product P1867, Plasmin from human plasma?
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The molecular weight of this dimeric protein was reported to be 75,400 Daltons. Reference is: The Plasma Proteins, Volume 1, 2nd ed., Putnam, F.W., ed., p. 66 (1975).
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Is there a conversion to International Units (I.U.) for Product P1867, Plasmin from human plasma?
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Sigma has not evaluated the activity of this enzyme in I.U., nor do we have a conversion factor.
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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