N194

NS-398

≥98% (HPLC), solid

• Synonym(s): N-[2-(Cyclohexyloxy)-4-nitrophenyl]methanesulfonamide
• Empirical Formula (Hill Notation): C₁₃H₁₈N₂O₅S
• CAS Number: 123653-11-2
• Molecular Weight: 314.36
• MDL number: MFCD00882995
• UNSPSC Code: 12352200
• PubChem Substance ID: 24897540
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: solid
• color: off-white
• mp: 127-128 °C
• solubility: DMSO: >5 mg/mL; H₂O: insoluble
• SMILES string: CS(=O)(=O)Nc1ccc(cc1OC2CCCCC2)[N+]([O-])=O
• InChI: 1S/C13H18N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h7-9,11,14H,2-6H2,1H3
• InChI key: KTDZCOWXCWUPEO-UHFFFAOYSA-N
• Gene Information: human ... ALOX5(240) , CYP19A1(1588) , PTGS1(5742) , PTGS2(5743) ; mouse ... Ptgs2(19225)

Description

Application

NS-398 has been used as a cyclooxygenase-2 (COX2) inhibitor to study its effects on:

• the cardiac rate in zebrafish embryos
• apoptosis and hypoxia/reoxygenation in rat cardiomyocytes
• the lipopolysaccharide (LPS) induced anorexia in rats

Biochem/physiol Actions

NS-398 belongs to the non-steroidal anti-inflammatory drug (NSAID) family. It exhibits anti-inflammatory, analgesic, and anti-pyretic properties.

Selective cyclooxygenase-2 (COX-2) inhibitor.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves