This product may be stored at room temperature in the powdered format. The solution stability of this material has not been determined. However, various external sources indicate that prepared solutions are stable up to 1 month when stored tightly sealed in aliquots at -20°C. This information has not been validated.
M5441
Mibefradil dihydrochloride hydrate
≥98% (HPLC), powder, T-type Ca²⁺ channel blocker
Synonym(s):
(1S,2S)-2-[2[[3-(2-Benzimidazolyl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphthyl methoxyacetate dihydrochloride hydrate, Ro 40-5967 hydrate
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About This Item
Empirical Formula (Hill Notation):
C29H38FN3O3 · 2HCl · xH2O
CAS Number:
Molecular Weight:
568.55 (anhydrous basis)
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Pricing and availability is not currently available.
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Product Name
Mibefradil dihydrochloride hydrate, ≥98% (HPLC), powder
Assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white
solubility
H2O: soluble >20 mg/mL
absolute ethanol: insoluble
originator
Roche
SMILES string
O.Cl.Cl.COCC(=O)O[C@]3(CCN(C)CCCc1nc2ccccc2[nH]1)CCc4cc(F)ccc4[C@@H]3C(C)C
InChI
1S/C29H38FN3O3.2ClH.H2O/c1-20(2)28-23-12-11-22(30)18-21(23)13-14-29(28,36-27(34)19-35-4)15-17-33(3)16-7-10-26-31-24-8-5-6-9-25(24)32-26;;;/h5-6,8-9,11-12,18,20,28H,7,10,13-17,19H2,1-4H3,(H,31,32);2*1H;1H2/t28-,29-;;;/m0.../s1
InChI key
IZSWBBGKLWFDOC-YKXHUFBBSA-N
Application
Biochem/physiol Actions
Mibefradil is a tetralol derivative and nondihydropyridine calcium channel blocker. It blocks long-type (L-type) calcium channels.[3][4] It blocks mildly the Purkinje-type (P-type) calcium channels in Purkinje neurons.[5]
Ro 40-5967 is a T-type Ca2+ channel blocker; antihypertensive.
Features and Benefits
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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