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D7571

Sigma-Aldrich

Dimaprit dihydrochloride

≥98% (NMR)

Synonym(s):

Carbamimidothioic acid, 3-(dimethylamino)propyl ester, hydrochloride (1:2), Dimaprit-2HCl

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About This Item

Empirical Formula (Hill Notation):
C6H15N3S · 2HCl
CAS Number:
23256-33-9
Molecular Weight:
234.19
MDL number:
MFCD00069260
UNSPSC Code:
12352200
PubChem Substance ID:
329798854
NACRES:
NA.77

Quality Level

100

Assay

≥98% (NMR)

form

powder

color

white to off-white

solubility

H2O: ≥50 mg/mL

originator

Roche

storage temp.

−20°C

SMILES string

Cl.Cl.CN(C)CCCSC(N)=N

InChI

1S/C6H15N3S.2ClH/c1-9(2)4-3-5-10-6(7)8;;/h3-5H2,1-2H3,(H3,7,8);2*1H

InChI key

DFWCPLGXFMSUCW-UHFFFAOYSA-N

Biochem/physiol Actions

The histamine H2 receptor influences various cardiovascular responses, including vasodilation and cardiac rhythm, regulates gastric acid secretion, and also plays a role in the immune system by inhibiting antibody production, T cell proliferation and cytokine production. Histamine receptors are members of the GPCR family, and H2 mediates cell signaling via internalization and interaction with the GTPase dynamin.

Features and Benefits

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Hamid Ghasemi et al.
Pharmacological reports : PR, 69(6), 1393-1401 (2017-11-18)
Histamine and opiate systems contribute to supraspinal processing of pain. In the present study, we investigated the effects of microinjection of histamine and agonists and antagonists of histamine H The thalamic ventral posterolateral nuclei were bilaterally implanted with two guide
J Kitanaka et al.
Neuroscience, 147(3), 765-777 (2007-06-16)
The administration of methamphetamine (METH, 10 mg/kg, i.p.) to male ICR mice induced stereotyped behavior consisting of nail and/or wood chip biting (86.0%), continuous sniffing (12.0%), head bobbing (1.1%), and circling (1.0%) during the observation period of 1 h. Pretreatment
Binu Kundukad et al.
Biophysical journal, 99(6), 1906-1915 (2010-09-23)
The flow properties of DNA are important for understanding cell division and, indirectly, cancer therapy. DNA topology controlling enzymes such as topoisomerase II are thought to play an essential role. We report experiments showing how double-strand passage facilitated by topoisomerase II
J Sethi et al.
Neuroscience, 217, 84-95 (2012-05-15)
Histamine acts centrally to increase energy expenditure and reduce body weight by mechanisms not fully understood. It has been suggested that in the obese state hypothalamic histamine signaling is altered. Previous studies have also shown that histamine acting in the
Parastoo Hashemi et al.
Journal of neurochemistry, 118(5), 749-759 (2011-06-21)
Exploring the mechanisms of serotonin [5-hydroxytryptamine (5-HT)] in the brain requires an in vivo method that combines fast temporal resolution with chemical selectivity. Fast-scan cyclic voltammetry is a technique with sufficient temporal and chemical resolution for probing dynamic 5-HT neurotransmission
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