There is not any data on how this or any of our antibodies will work on frozen tissue. They were only used to run testing on 10% NBF processed tissue. It might be worth purchasing the smallest size and testing it to see if it would work for your conditions.
101R-1
CD1a (EP3622) Rabbit Monoclonal Primary Antibody
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
Pricing and availability is not currently available.
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biological source
rabbit
Quality Level
100
500
conjugate
unconjugated
antibody form
culture supernatant
antibody product type
primary antibodies
clone
EP3622, monoclonal
description
For In Vitro Diagnostic Use in Select Regions (See Chart)
form
buffered aqueous solution
species reactivity
human
packaging
vial of 0.1 mL concentrate (101R-14)
vial of 0.5 mL concentrate (101R-15)
bottle of 1.0 mL predilute (101R-17)
pkg of 1.0 mL concentrate (101R-16)
bottle of 7.0 mL predilute (101R-18)
manufacturer/tradename
Cell Marque®
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)
isotype
IgG1
control
skin, thymus
shipped in
wet ice
storage temp.
2-8°C
visualization
membranous
Gene Information
human ... CD1A(909)
General description
CD1a is a non-polymorphic, major histocompatibility complex, class I-related cell surface glycoprotein (45 to 55 kDa), and is expressed in association with β-microglobulin.[1] In normal tissues, anti-CD1a reacts with cortical thymocytes, Langerhans cells, interdigitating cells, and rare antigen-presenting cells of the lymph node.[2] CD1a positivity has also been seen in Langerhans cell histiocytosis (histiocytosis X)[3], and a subset of pre-T lymphoblastic lymphoma/leukemia (cortical T LBL/L).[4]
Quality
 IVD |  IVD |  IVD |  RUO |
Linkage
CD1a Positive Control Slides, Product No. 101S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Preparation Note
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Other Notes
For Technical Service please contact: 800-665-7284 or email: [email protected]
Legal Information
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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J F Emile et al.
The American journal of surgical pathology, 19(6), 636-641 (1995-06-01)
The histological and immunohistochemical findings of 34 biopsy specimens from patients with Langerhans' cell histiocytosis (LCH) are reported, with special emphasis on the findings with CD1a mouse monoclonal antibody (MAb) O10 using paraffin-embedded material. Eighteen patients were treated in an
Catherine E Angel et al.
Blood, 113(6), 1257-1267 (2008-11-07)
Professional antigen-presenting cells (APCs) are sentinel cells of the immune system that present antigen to T lymphocytes and mediate an appropriate immune response. It is therefore surprising that knowledge of the professional APCs in human lymph nodes is limited. Using
Samir Dalia et al.
Cancer control : journal of the Moffitt Cancer Center, 21(4), 322-327 (2014-10-14)
Rosai-Dorfman disease (RDD) is a rare, nonmalignant clinical entity characterized by a group of clinical symptoms and characteristic pathological features. Articles that reviewed tumor biology, clinical features, pathology, and treatment for RDD were identified in a search of the literature
Xin Han et al.
American journal of clinical pathology, 127(4), 528-544 (2007-03-21)
Session 4 of the 2005 Society of Hematopathology/European Association for Haematopathology Workshop focused on case presentations of precursor T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma (pre-T ALL/LBL) and acute biphenotypic leukemia. Pre-T ALL represents approximately 15% of childhood and 25% of adult
L Krenács et al.
The Journal of pathology, 171(2), 99-104 (1993-10-01)
The immunoreactivity of a CD1a monoclonal antibody (MAb), denoted 010, was investigated by means of the streptavidin-biotin-peroxidase method in formalin-fixed and paraffin-embedded tissues from 47 cases. The samples comprised reactive lymphoid proliferations of skin, tonsil, and lymph node including dermatopathic
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Can the CD1a (EP3622) Rabbit Monoclonal Primary Antibody be used with frozen human tissue? are there any similar products that can be used on frozen tissue?
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