Skip to Content
Merck
All Photos(7)

Documents

207772

Sigma-Aldrich

Iodine

ACS reagent, ≥99.8%, solid

Sign Into View Organizational & Contract Pricing
All Photos(7)

About This Item

Empirical Formula (Hill Notation):
I2
CAS Number:
7553-56-2
Molecular Weight:
253.81
Beilstein:
3587194
EC Number:
231-442-4
MDL number:
MFCD00011355
UNSPSC Code:
12141916
eCl@ss:
38050601
PubChem Substance ID:
329752021
NACRES:
NA.21

grade

ACS reagent

Quality Level

200

vapor density

9 (vs air)

vapor pressure

0.31 mmHg ( 25 °C)
1 mmHg ( 38.7 °C)

Assay

≥99.8%

form

solid

resistivity

1.3E15 μΩ-cm

impurities

≤0.01% nonvolatiles

bp

184 °C (lit.)

mp

113 °C (lit.)

anion traces

Cl- and Br-: ≤0.005%

storage temp.

room temp

SMILES string

II

InChI

1S/I2/c1-2

InChI key

PNDPGZBMCMUPRI-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

General description

Iodine exhibits exceptionally high dielectric polarization in various solvents (dioxane, isobutylene, p-xylene and benzene).

Application

Catalyst for synthesis of esters by condensation of carboxylic acids with alcohols or transfesterification.

A mild and efficient method for esterification and transesterification catalyzed by iodine
Iodine has been used for the easy visualization of 9-bromononanoic acid, allyl ester by thin layer chromatography (TLC). It has also been used for the preparation of oxidation solution, required for the synthesis of oligodeoxynucleotides bearing 3′-terminal phosphorothioate.
Iodine may be used to catalyze:
  • Synthesis of 5-(4-nitrophenyl)-10,15,20-triphenylporphyrin.
  • Oxidative C-H bond amination of saturated hydrocarbons.
  • Protection of amines with benzyloxycarbonyl (Cbz) group.
  • Direct oxidative coupling/annulation of β-keto esters or 2-pyridinyl-β-esters with alkenes to form dihydrofurans and indolizine, respectively.
  • Thiocyanation of aromatic systems to form aryl thiocyanates.
  • Esterification of cellulose with acetic anhydride to form cellulose triacetate.

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3

Target Organs

Respiratory system, Thyroid

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Iodine-catalyzed one-pot synthesis of unsymmetrical meso-substituted porphyrins.
Boens B, et al.
Tetrahedron, 66(11), 1994-1996 (2010)
Iodine-Catalyzed Radical Oxidative Annulation for the Construction of Dihydrofurans and Indolizines.
Tang S, et al.
Organic Letters, 17(10), 2404-2407 (2015)
An Iodine-Catalyzed Hofmann-Loffler Reaction.
Martinez C and Mu?iz K.
Angewandte Chemie (International Edition in English), 54(28), 8287-8291 (2015)
Molecular iodine-catalyzed efficient N-Cbz protection of amines.
Varala R, et al.
Journal of the Iranian Chemical Society, 4(3), 370-374 (2007)
Iodine/MeOH: a novel and efficient reagent system for thiocyanation of aromatics and heteroaromatics.
Yadav JS, et al.
Tetrahedron Letters, 45(14), 2951-2954 (2004)
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service