S3674

Succinic acid

BioXtra, BioRenewable, ≥99.0%

• Synonym(s): Butanedioic acid
• Linear Formula: HOOCCH₂CH₂COOH
• CAS Number: 110-15-6
• Molecular Weight: 118.09
• Beilstein: 1754069
• EC Number: 203-740-4
• MDL number: MFCD00002789
• UNSPSC Code: 12352106
• PubChem Substance ID: 24899568
• NACRES: NA.25

Properties

• Quality Level: 200
• product line: BioXtra
• Assay: ≥99.0%
• greener alternative product characteristics: Use of Renewable Feedstocks; Learn more about the Principles of Green Chemistry.
• sustainability: Greener Alternative Product
• impurities: ≤0.01% Insoluble matter
• ign. residue: ≤0.02%
• bp: 235 °C (lit.)
• mp: 184-186 °C (lit.)
• solubility: H₂O: 0.5 M, clear, colorless
• anion traces: chloride (Cl^-): ≤0.001%; sulfate (SO₄^2-): ≤0.003%
• cation traces: Al: ≤0.0005%; Ca: ≤0.001%; Cu: ≤0.0005%; Fe: ≤0.0005%; K: ≤0.005%; Mg: ≤0.0005%; NH₄⁺: ≤0.05%; Na: ≤0.005%; Pb: ≤0.001%; Zn: ≤0.0005%
• greener alternative category: , Aligned
• SMILES string: OC(=O)CCC(O)=O
• InChI: 1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)
• InChI key: KDYFGRWQOYBRFD-UHFFFAOYSA-N

Description

General description

We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product is biobased and thus aligns with "Use of Renewable Feedstocks". Click here for more information.

Application

Succinic acid has been used:

• in succinate dehydrogenase mitochondrial assay.[1]
• as an internal standard in mass spectroscopy.[2]
• as succinate dehydrogenase substrate in oxygraph analysis to measure respiration rates.[3]

Biochem/physiol Actions

Succinic acid is a byproduct of anaerobic fermentation in microbes. It is a dicarboxylic acid and an intermediate in Kreb′s cycle.[4] Polymorphism in succinate dehydrogenase leads to succinate accumulation. High levels of succinate impairs 2-oxoglutarate epigenetic signalling.[5] Succinate levels may modulate tumor progression.[6] Succinate inhibits histone demethylation and may contribute to epigenetic changes.[7] Succinate is crucial for interleukin-1 β (IL-1β) synthesis during inflammation and immune signalling.[8]

Other Notes

Succinic Acid: A New Platform Chemical for Biobased Polymers from Renewable Resources

Safety Information

• Pictograms: GHS05
• Signal Word: Danger
• Hazard Statements: H318
• Precautionary Statements: P280 - P305 + P351 + P338
• Hazard Classifications: Eye Dam. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves