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M9017

Supelco

Mepirizole

analytical standard

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About This Item

Empirical Formula (Hill Notation):
C11H14N4O2
CAS Number:
18694-40-1
Molecular Weight:
234.25
EC Number:
242-507-1
MDL number:
MFCD00057351
UNSPSC Code:
41116107
PubChem Substance ID:
329818077
NACRES:
NA.24

grade

analytical standard

Quality Level

200

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

storage temp.

2-8°C

SMILES string

CC1=NC(N2C(OC)=CC(C)=N2)=NC(OC)=C1

InChI

1S/C11H14N4O2/c1-7-5-9(16-3)13-11(12-7)15-10(17-4)6-8(2)14-15/h5-6H,1-4H3

InChI key

RHAXSHUQNIEUEY-UHFFFAOYSA-N

General description

Mepirizole belongs to the class of non-steroidal anti-inflammatory drugs (NSAIDs), widely used in the treatment of pain and inflammation.

Application

Mepirizole may be used as an analytical reference standard for the quantification of the analyte in animal samples using ultra-high-performance liquid chromatography with tandem mass spectrometry.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
066H0190
012H0713

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F Iwata et al.
Digestive diseases and sciences, 40(5), 1112-1117 (1995-05-01)
The hyperemia at the duodenal ulcer margin is important for ulcer healing. We studied the effect of tobacco cigarette smoke on the hyperemia at the margin of mepirizole-induced duodenal ulcer. Duodenal mucosal blood flow values measured by iodo[14C]antipyrine (IAP) autoradiography
S Evangelista et al.
Neuroscience letters, 112(2-3), 352-355 (1990-05-04)
Substance P-like immunoreactivity (SP-li) is decreased in duodenal samples of animals treated with a single dose of an ulcerogen such as dulcerozine, mepirizole or cysteamine. Unlike dulcerozine- or mepirizole-induced ulcers the degree of cysteamine-induced duodenal lesions is inversely correlated with
D Renzi et al.
Advances in experimental medicine and biology, 298, 129-135 (1991-01-01)
We have investigated the endogenous levels of duodenal calcitonin gene-related peptide- (CGRP) and Substance P- (SP) like immunoreactivity (li) following the induction of duodenal ulcers in rats. Using three duodenal ulcerogens, namely cysteamine, dulcerozine or mepirizole given in a single
K Takeuchi et al.
Digestive diseases and sciences, 40(3), 670-677 (1995-03-01)
The inhibition of nitric oxide (NO) production by NO synthase inhibitors stimulates HCO3- secretion in the rat duodenal mucosa. Therefore, we examined the effects of NG-nitro-L-arginine methyl ester (L-NAME, the NO synthase inhibitor) and nitroprusside (the exogenous NO donor) on
K Amagase et al.
Arzneimittel-Forschung, 46(2), 177-184 (1996-02-01)
The effects of (+/-)-(E)-1-[2-hydroxy-2-(4-hydroxyphenyl)ethyl]-3-[2- [[[5-(methylamino)methyl-2-furyl] methyl]thio]ethyl]-2-(methylsulfonyl)guanidine (CAS 140695-21-2, T-593), a new histamine H2-receptor antagonist, on gastric secretion and experimental gastric and duodenal lesion/ulcer models in rats were examined. The drug administered orally or intraduodenally significantly and dose-dependently inhibited both basal
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