SCC147
TPC-1 Human Papillary Thyroid Carcinoma Cell line
Human
Synonym(s):
TPC1
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About This Item
UNSPSC Code:
41106514
eCl@ss:
32011203
NACRES:
NA.81
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product name
TPC-1 Human Papillary Thyroid Carcinoma Cell line, TPC-1 human papillary thyroid carcinoma cell line is a highly characterized model for thyroid cancer research.
biological source
human
technique(s)
cell culture | mammalian: suitable
shipped in
ambient
General description
TPC-1 is a widely published and well-characterized cell line isolated from a papillary thyroid carcinoma of a female patient (6). The genome of TPC-1 contains the RET/PTC1 rearrangement found in approximately 20% of sporadic papillary carcinomas in adults (2). TPC-1 harbors a silent polymorphism in H-RAS, and is wild-type for sequences of BRAF, CNBB1, EGFR, K-RAS, RAF-1, PI3K, and TRHB (3). TPC-1 cells produce thyroglobulin (Tg) as well as expressing the thyroid differentiation marker PAX8 and the tumor progression factor podoplanin (4). In addition, TPC-1 has been utilized as an in vitro model for human cytomegalovirus latency, a potential contributor for certain human cancers (5). The TPC-1 cell line is thus an excellent system for investigating mechanisms of thyroid carcinogenesis.
Thyroid cancer is the most prevalent endocrine carcinoma, with a rapidly increasing occurrence in many countries. Human models of differentiated thyroid cancer are highly valuable for assessing the pathways and mechanisms that contribute to thyroid carcinogenesis.
References:
1. Davies L, Welch HG (2006). Increasing incidence of thyroid cancer in the United States, 1973-2002. JAMA 295(18): 2164-2167.
2. Pilli T, et al. (2009). Potential utility and limitations of thyroid cancer cell lines as models for studying thyroid cancer. Thyroid 19(12): 1333-1342.
3. Meireles AM, et al. (2007). Molecular and genotypic characterization of human thyroid follicular cell carcinoma-derived cell lines. Thyroid 17(8): 707-715.
4. Rudzińska M, et al. (2014). The role of podoplanin in the biology of differentiated thyroid cancers. PLoS One 9(5): e96541.
5. Tanaka J, et al. (1987). Establishment and biological characterization of an in vitro human cytomegalovirus latency model. Virology 161(1): 62-72.
6. Ishizaka Y, et al. (1989). Presence of aberrant transcripts of ret proto-oncogene in a human papillary thyroid carcinoma cell line. Jpn J Cancer Res 80(12): 1149-1152.
References:
1. Davies L, Welch HG (2006). Increasing incidence of thyroid cancer in the United States, 1973-2002. JAMA 295(18): 2164-2167.
2. Pilli T, et al. (2009). Potential utility and limitations of thyroid cancer cell lines as models for studying thyroid cancer. Thyroid 19(12): 1333-1342.
3. Meireles AM, et al. (2007). Molecular and genotypic characterization of human thyroid follicular cell carcinoma-derived cell lines. Thyroid 17(8): 707-715.
4. Rudzińska M, et al. (2014). The role of podoplanin in the biology of differentiated thyroid cancers. PLoS One 9(5): e96541.
5. Tanaka J, et al. (1987). Establishment and biological characterization of an in vitro human cytomegalovirus latency model. Virology 161(1): 62-72.
6. Ishizaka Y, et al. (1989). Presence of aberrant transcripts of ret proto-oncogene in a human papillary thyroid carcinoma cell line. Jpn J Cancer Res 80(12): 1149-1152.
Cell Line Description
Cancer Cells
Application
Research Category
Cancer
Oncology
Cancer
Oncology
TPC-1 human papillary thyroid carcinoma cell line is a highly characterized model for thyroid cancer research.
This product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@emdmillipore.com.
Quality
• Each vial contains ≥ 1X10⁶ viable cells.
• Cells are tested negative for infectious diseases by a Human Essential CLEAR panel by Charles River Animal Diagnostic Services.
• Cells are negative for mycoplasma contamination.
• Cells are verified to be of human origin and negative for inter-species contamination from mouse, rat, chinese hamster, Golden Syrian hamster, and non-human primate (NHP) as assessed by a Contamination CLEAR panel by Charles River Animal Diagnostic Services.
• Each lot of cells is genotyped by STR analysis to verify the unique identity of the cell line.
• Cells are tested negative for infectious diseases by a Human Essential CLEAR panel by Charles River Animal Diagnostic Services.
• Cells are negative for mycoplasma contamination.
• Cells are verified to be of human origin and negative for inter-species contamination from mouse, rat, chinese hamster, Golden Syrian hamster, and non-human primate (NHP) as assessed by a Contamination CLEAR panel by Charles River Animal Diagnostic Services.
• Each lot of cells is genotyped by STR analysis to verify the unique identity of the cell line.
Storage and Stability
Store in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Renuka Raman et al.
The Journal of experimental medicine, 219(6) (2022-05-06)
Genetic alterations in RET lead to activation of ERK and AKT signaling and are associated with hereditary and sporadic thyroid cancer and lung cancer. Highly selective RET inhibitors have recently entered clinical use after demonstrating efficacy in treating patients with
Mingming Wang et al.
Journal of cell communication and signaling, 15(2), 237-250 (2020-10-16)
Due to the steadily rising morbidity and mortality, thyroid cancer remains the most commonly seen endocrine cancer. The present study attempted to investigate the mechanism from the perspective of long non-coding RNA (lncRNA) regulation. We identified 53 markedly increased lncRNAs
Yu Mao et al.
Endocrine journal, 68(11), 1267-1281 (2021-06-11)
Circular RNA 40S ribosomal protein S28 (circRPS28; hsa_circ_0049055) is upregulated in papillary thyroid carcinoma (PTC) patients. However, its role remained uncovered in the progression of PTC. Above all, expression of circRPS28 was determined in PTC samples by real-time quantitative PCR
Hao Jia et al.
Bioengineered, 13(4), 9588-9601 (2022-04-13)
Melatonin (MEL) is an effective therapeutic choice for thyroid cancer treatment. In this study, we aimed to explored the potential effect of MEL upon the drug sensitivity of cancer cells and the according underlying mechanisms. Thyroid cancer mice were established
Huanquan Lu et al.
Development, growth & differentiation, 62(2), 129-138 (2020-01-09)
Thyroid cancer (TC) is the most common malignant endocrine tumor, and its incidence has progressively increased over several decades. Accumulating evidence has suggested that PFKFB4, a critical regulatory enzyme of glycolysis, has been implicated in various solid cancers. However, the
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