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SAB2702233

Sigma-Aldrich

Monoclonal Anti-Dengue virus Envelope protein antibody produced in mouse

clone GT643, affinity isolated antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

GT643, monoclonal

form

buffered aqueous solution

mol wt

51-60kDa

species reactivity

Dengue virus

concentration

1mg/mL

technique(s)

flow cytometry: suitable
immunofluorescence: 1:100-1:2,000
western blot: 1:500-1:3,000

isotype

IgG2b

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Related Categories

General description

Dengue virus is an arthropod borne flavivirus. Dengue virus (DENV) is a human pathogen, known to cause one of the major illness, dengue fever (DF) in humans. DENV belongs to the Flaviviridae family. The virus attaches and enters the host cell with the help of a major envelope protein glycoprotein, E. The dengue envelope protein sequence consists of two putative glycosaminoglycan-binding motifs at the carboxy terminus.

Immunogen

Recombinant protein encompassing a sequence within the center region of Dengue virus Envelope protein.

Application

Suggested starting dilutions are as follows: ICC/IF: 1:100-1:2000, WB: 1:500-1:3000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Other Notes

Purification: Affinity purified by Protein G

Physical form

Phosphate-buffered saline, no preservative added.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Dengue virus infectivity depends on envelope protein binding to target cell heparan sulfate.
Chen Y, et al.
Nature Medicine, 3(8), 866-866 (1997)
Ankit Kumar et al.
Asian journal of transfusion science, 16(1), 67-72 (2022-10-07)
The study objective was evaluation of amotosalen and ultraviolet A (UVA) illumination-based inactivation of dengue virus (DENV) in blood platelets. Whole blood was collected from healthy donors and platelet concentrates were prepared at a tertiary care hospital in Gurugram, India.
Type-and subcomplex-specific neutralizing antibodies against domain III of dengue virus type 2 envelope protein recognize adjacent epitopes.
Sukupolvi-Petty S, et al.
Journal of Virology, 81(23), 12816-12826 (2007)
A ligand-binding pocket in the dengue virus envelope glycoprotein.
Modis Y, et al.
Proceedings of the National Academy of Sciences of the USA, 100(12), 6986-6991 (2003)

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