SAB1305638

ANTI-LC3 (APG8A) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• Synonym(s): Autophagy-related protein LC3 A, Autophagy-related ubiquitin-like modifier LC3 A, MAP1 light chain 3-like protein 1, MAP1LC3A, Microtubule-associated proteins 1A/1B light chain 3A
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• antibody form: IgG fraction of antiserum
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: 14272 Da
• species reactivity: human
• technique(s): immunofluorescence: 1:200; western blot: 1:1000
• NCBI accession no.: NP_115903.1
• UniProt accession no.: Q9H492
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... MAP1LC3A(84557)

Description

General description

The gene autophagy-related protein 8A (APG8A), also referred to as MAP1LC3A (microtubule associated protein 1 light chain 3 α), is a homologue of Apg8p necessary for autophagy in yeast. The cytosolic form of the protein, upon processing, gets localized to the autophagosome membranes. The LC3 gene is mapped to human chromosome 20q11.22.

Biochem/physiol Actions

The gene MAP1LC3A (microtubule associated protein 1 light chain 3 α) or LC3 or autophagy-related protein 8A (APG8A) encodes a protein that serves as a marker of autophagosomes. It is found to be expressed on surviving oligodendrocytes in Nasu-Hakola disease brains and may be involved in the induction of oligodendrogliopathy.

Physical form

Supplied in PBS with 0.09% (W/V) sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable