Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

S0193

Sigma-Aldrich

SKF-86002

≥98% (HPLC), solid

Synonym(s):

6-(4-Fluorophenyl)-5-(4-pyridyl)-2,3-dihydroimidazo[2,1-b]-thiazole

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C16H12N3FS
CAS Number:
72873-74-6
Molecular Weight:
297.35
MDL number:
MFCD00869367
UNSPSC Code:
12352200
PubChem Substance ID:
24724598
NACRES:
NA.77

Assay

≥98% (HPLC)

form

solid

storage condition

protect from light

color

off-white

mp

189-190 °C (lit.)

solubility

DMSO: soluble >10 mg/mL

storage temp.

2-8°C

SMILES string

Fc1ccc(cc1)-c2nc3SCCn3c2-c4ccncc4

InChI

1S/C16H12FN3S/c17-13-3-1-11(2-4-13)14-15(12-5-7-18-8-6-12)20-9-10-21-16(20)19-14/h1-8H,9-10H2

InChI key

YOELZIQOLWZLQC-UHFFFAOYSA-N

Gene Information

human ... IL1B(3553) , TNF(7124)
rat ... Alox5(25290)

Biochem/physiol Actions

p38 MAP kinase inhibitor.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

M Pouliot et al.
Journal of immunology (Baltimore, Md. : 1950), 158(10), 4930-4937 (1997-05-15)
Prostaglandin endoperoxide synthase (PGHS; cyclooxygenase), the rate-limiting enzyme in the conversion of arachidonic acid to prostanoids, has two isoforms. PGHS-1 is constitutively expressed and involved in homeostasis, whereas PGHS-2 is inducible in monocytes in response to proinflammatory agents. Using freshly
Maria Tsirigotis et al.
PloS one, 3(5), e2130-e2130 (2008-05-08)
The signaling pathways that may modulate the pathogenesis of diseases induced by expanded polyglutamine proteins are not well understood. Herein we demonstrate that expanded polyglutamine protein cytotoxicity is mediated primarily through activation of p38MAPK and that the atypical PKC iota
Donna E Muscarella et al.
Toxicological sciences : an official journal of the Society of Toxicology, 68(1), 82-92 (2002-06-21)
Various forms of inorganic arsenic are significant environmental contaminants that have multiple effects on cells, including the induction of apoptotic cell death. Induction of apoptosis in lymphoid cells can mediate immunotoxicity following exposure to chemicals. However, the mechanisms regulating the
S Su et al.
BioTechniques, 22(6), 1107-1113 (1997-06-01)
We have developed a high-throughput, multiplex reverse transcription PCR (RTPCR) assay that is suitable for the analysis of medium-to low-copy cellular RNA transcripts from small numbers of cells (10(4)). High throughput was attained by utilizing microplate-based RNA extraction and RTPCR
J C Lee et al.
Immunopharmacology, 47(2-3), 185-201 (2000-07-06)
Since the discovery of p38 MAP kinase in 1994, our understanding of its biology has progressed dramatically. The key advances include (1) identification of p38 MAP kinase homologs and protein kinases that act upstream and downstream from p38 MAP kinase
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service