B1427

H-89 dihydrochloride hydrate

≥98% (HPLC), powder, PKA inhibitor

• Synonym(s): N-[2-(p-Bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide dihydrochloride
• Empirical Formula (Hill Notation): C₂₀H₂₀BrN₃O₂S · 2HCl · xH₂O
• CAS Number: 130964-39-5
• Molecular Weight: 519.28 (anhydrous basis)
• MDL number: MFCD11045926
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278256
• NACRES: NA.77

Properties

• product name: H-89 dihydrochloride hydrate, ≥98% (HPLC), powder
• biological source: synthetic (organic)
• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: off-white
• solubility: DMSO: 10 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O.Cl.Cl.Brc1ccc(\C=C\CNCCNS(=O)(=O)c2cccc3cnccc23)cc1
• InChI: 1S/C20H20BrN3O2S.2ClH.H2O/c21-18-8-6-16(7-9-18)3-2-11-22-13-14-24-27(25,26)20-5-1-4-17-15-23-12-10-19(17)20;;;/h1-10,12,15,22,24H,11,13-14H2;2*1H;1H2/b3-2+;;;
• InChI key: GKFFJFGBWAGAFD-HZBIHQSRSA-N
• Gene Information: human ... PRKAR1A(5573) , PRKAR1AP(5574) , PRKAR1B(5575) , PRKAR2A(5576) , PRKAR2B(5577)

Description

Application

H-89 dihydrochloride hydrate has been used in the inhibition of protein kinase A in Leydig cells, primary calvarial osteoblasts (pOBs), rat granulosa cell line (LH-15 cells) and human umbilical vein endothelial cells (HUVECs).

Biochem/physiol Actions

H-89 dihydrochloride hydrate is a selective inhibitor of protein kinase A (PKA). It also inhibits potassium (K⁺) current in rat myocytes. It mediates Na⁺ transport by interacting with α subunits of epithelial Na⁺ channel (ENaC).

Selective, potent inhibitor of cAMP-dependent protein kinase.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the PKA & PKG and PKB/Akt pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves