A8381

L-Asparagine monohydrate

≥99% (TLC)

• Synonym(s): (S)-(+)-2-Aminosuccinamic acid, (S)-2-Aminosuccinic acid 4-amide, L-Aspartic acid 4-amide
• Linear Formula: NH₂COCH₂CH(NH₂)COOH · H₂O
• CAS Number: 5794-13-8
• Molecular Weight: 150.13
• Beilstein: 1723527
• EC Number: 200-735-9
• MDL number: MFCD00151038
• UNSPSC Code: 12352209
• PubChem Substance ID: 24891338
• NACRES: NA.26

Properties

• product name: L-Asparagine monohydrate, ≥99% (TLC)
• biological source: synthetic
• Assay: ≥99% (TLC)
• form: powder
• color: white to off-white
• mp: 233-235 °C (lit.)
• application(s): cell analysis; peptide synthesis
• SMILES string: [H]O[H].N[C@@H](CC(N)=O)C(O)=O
• InChI: 1S/C4H8N2O3.H2O/c5-2(4(8)9)1-3(6)7;/h2H,1,5H2,(H2,6,7)(H,8,9);1H2/t2-;/m0./s1
• InChI key: RBMGJIZCEWRQES-DKWTVANSSA-N

Description

General description

Asparagine biosynthesis is catalyzed by glutamine-dependent asparagine synthetase in mammalian tissues. Elevated levels of free asparagine is observed in plants facing stress in the form of drought or high salt. It is also present in senescing leaves and germinating seeds.

Application

L-Asparagine monohydrate has been used:

• as a component of Sauton′s and chelated Sauton′s media for mycobacterial growth
• to test its effect in the induction of Ca²⁺ flux in rice roots using aequorin luminescence imaging
• as a component of fermentation medium for the Blakeslea trispora spores

Biochem/physiol Actions

Asparagine has high nitrogen to carbon ratio and is a key regulator for nitrogen storage and transport. Its thermal degradation in the presence of sugars leads to the acrylamide formation in foods. Asparagine serves as an amino acid exchange factor and is essential for amino acid homeostasis. It favors cancer cell proliferation.

L-Asparagine, a proteinogenic amino acid, is used in biomanufacturing cell culture systems for the production of therapeutic recombinant proteins and monoclonal antibodies and in cell culture based research.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves