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B7149

Sigma-Aldrich

Benzthiazide

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About This Item

Empirical Formula (Hill Notation):
C15H14ClN3O4S3
CAS Number:
91-33-8
Molecular Weight:
431.94
EC Number:
202-061-0
MDL number:
MFCD00078969
UNSPSC Code:
12352100
PubChem Substance ID:
57653955
NACRES:
NA.22

form

solid

SMILES string

NS(=O)(=O)c1cc2c(NC(CSCc3ccccc3)=NS2(=O)=O)cc1Cl

InChI

1S/C15H14ClN3O4S3/c16-11-6-12-14(7-13(11)25(17,20)21)26(22,23)19-15(18-12)9-24-8-10-4-2-1-3-5-10/h1-7H,8-9H2,(H,18,19)(H2,17,20,21)

InChI key

NDTSRXAMMQDVSW-UHFFFAOYSA-N

Gene Information

human ... SLC12A3(6559)

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Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H317,H334

Precautionary Statements

P261 - P280 - P342 + P311

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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M C Meyer et al.
Biopharmaceutics & drug disposition, 3(1), 1-9 (1982-01-01)
An assay was developed for benzthiazide in plasma, urine and feces, using high performance liquid chromatography (HPLC). A reverse-phase column was employed, with quantitation af 280 nm, using polythiazide as an internal standard. In three of four human subjects who
R A Adler et al.
Metabolism: clinical and experimental, 35(7), 668-672 (1986-07-01)
There is evidence that prolactin (PRL) excess plays a role in the etiology of osteoporosis associated with human prolactinoma. Calcium balance in human hyperprolactinemia has not been thoroughly investigated. In the present study, rats with excess circulating PRL levels (male
Thiazides XIII: Dissolution testing: a bioavailability predictor for benzthiazide tablets.
V P Shah et al.
Biopharmaceutics & drug disposition, 3(3), 283-285 (1982-07-01)
L R Berkowitz
The American journal of physiology, 258(4 Pt 1), C622-C629 (1990-04-01)
The thioalkylating agent N-ethylmaleimide (NEM) causes ouabain-insensitive K loss from human red blood cells. This K loss is inhibited when intracellular Cl is replaced by another permeant anion or when loop diuretics are placed in the incubation medium after NEM
Laurie De Wilde et al.
Journal of chromatography. A, 1579, 31-40 (2018-11-16)
Diuretics can be misused to force diuresis to achieve weight loss or to mask the intake of a prohibited substance and are therefore prohibited by the World Anti-Doping Agency (WADA). For similar reasons other masking agents (vaptans, probenecid, etc.) are
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