1154004

Cyclizine hydrochloride

United States Pharmacopeia (USP) Reference Standard

• Synonyme(s) : 1-Benzhydryl-4-methylpiperazine hydrochloride, Marezine hydrochloride
• Formule empirique (notation de Hill): C₁₈H₂₂N₂ · HCl
• Numéro CAS: 303-25-3
• Poids moléculaire : 302.84
• Code UNSPSC : 41116107
• Nomenclature NACRES : NA.24

Propriétés

• Qualité: pharmaceutical primary standard
• Famille d'API: cyclizine
• Fabricant/nom de marque: USP
• Application(s): pharmaceutical (small molecule)
• Format: neat
• Température de stockage: 2-8°C
• InChI: 1S/C18H22N2.ClH/c1-19-12-14-20(15-13-19)18(16-8-4-2-5-9-16)17-10-6-3-7-11-17;/h2-11,18H,12-15H2,1H3;1H
• Clé InChI: UKPBEPCQTDRZSE-UHFFFAOYSA-N

Description

Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

• Apoptotic pathways in macrophages: Cyclizine hydrochloride was studied for its ability to induce cytotoxicity and apoptosis in macrophages through both extrinsic and intrinsic pathways, suggesting its potential implications in immunomodulatory therapies (Lu et al., 2024).


• Chemometric methods in impurity analysis: Advanced chemometric methods have been employed to determine cyclizine hydrochloride along with other compounds in pharmaceutical products, highlighting its importance in ensuring the purity and efficacy of drug formulations (Saad et al., 2022).


• Anti-inflammatory effects in pharmacology: Cyclizine derivatives were synthesized and evaluated for anti-inflammatory performance on Wistar rats, providing insights into the therapeutic potential of cyclizine modifications in treating inflammation (Ahmadi et al., 2012).

Remarque sur l'analyse

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Autres remarques

Sales restrictions may apply.

Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H301
• Conseils de prudence: P264 - P270 - P301 + P310 - P405 - P501
• Classification des risques: Acute Tox. 3 Oral
• Code de la classe de stockage: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable