X0379

Xanthohumol

powder, ≥96% (HPLC)

• Synonyme(s) : (E)-1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)propenone, 2′,4,4′-Trihydroxy-6′-methoxy-3′-prenylchalcone
• Formule empirique (notation de Hill): C₂₁H₂₂O₅
• Numéro CAS: 6754-58-1
• Poids moléculaire : 354.40
• Numéro MDL: MFCD00210576
• Code UNSPSC : 12352204
• ID de substance PubChem : 24902121
• Nomenclature NACRES : NA.77

Propriétés

• product name: Xanthohumol from hop (Humulus lupulus), ≥96% (HPLC)
• Source biologique: plant (Humulus lupulus)
• Pureté: ≥96% (HPLC)
• Forme: powder
• Pf: 172 °C
• Solubilité: ethanol: 10 mg/mL
• Température de stockage: 2-8°C
• Chaîne SMILES: COc1cc(O)c(C\C=C(/C)C)c(O)c1C(=O)\C=C\c2ccc(O)cc2
• InChI: 1S/C21H22O5/c1-13(2)4-10-16-18(24)12-19(26-3)20(21(16)25)17(23)11-7-14-5-8-15(22)9-6-14/h4-9,11-12,22,24-25H,10H2,1-3H3/b11-7+
• Clé InChI: ORXQGKIUCDPEAJ-YRNVUSSQSA-N

Description

Description générale

Xanthohumol is a chalcone compound present in the female inflorescence of hop (Humulus lupulus) plant. It is a food additive.

Application

Xanthohumol from hop (Humulus lupulus) has been used:

• to treat glioblastoma cells to test its effect on inducing apoptosis
• to test its protective effect in renal ischemia/reperfusion (I/R) injury
• as a component of Dulbecco′s modified Eagle medium (DMEM) to test its antiviral activity in Huh7.5 cells infected with hepatitis C virus cell culture (HCVcc) system

Actions biochimiques/physiologiques

Prenylated flavonoids such as xanthohumol have antiproliferative and cytotoxic effects in human cancer cell lines. Xanthohumol protected HepG2 cells against benzo[a]pyrene and related carcinogens. It also protected against reactive oxygen species (ROS), not by a direct anti-oxidant effect, but instead mediated by induction of cellular defense mechanisms against oxidative stress.Xanthohumol inhibits diacylglycerol acetyltransferase (DGAT) and human P450 enzymes. It also inhibits the expression of HIF-1α and VEGF under hypoxic conditions.

Xanthohumol induces apoptosis in glioma cancer by modulating microRNA based network. It exhibits anti-inflammatory property by inhibiting janus kinases (JAKs), signal transducer and activator of transcription proteins (STATs). Xanthohumol elicits antiviral functionality against bovine viral diarrhea virus (BVDV) and anti-hepatitis C virus in vitro. It also induces autophagy and has antiplatelet and neuroprotective effects. Xanthohumol also regulates various metabolic processes including the inhibition of triglyceride formation, atherosclerotic plaque and adipogenesis.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves