Accéder au contenu
Merck
Toutes les photos(1)

Documents

UC168

Sigma-Aldrich

(±)-Bufuralol hydrochloride

≥98% (HPLC), solid, β-Adrenoceptor agonist/antagonist

Synonyme(s) :

α-[(tert-Butylamino)methyl]-7-ethyl-2-benzofuranmethanol hydrochloride

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
Toutes les photos(1)

About This Item

Formule empirique (notation de Hill):
C16H23NO2·HCl
Numéro CAS:
60398-91-6
Poids moléculaire :
297.82
Numéro CE :
262-216-3
Numéro MDL:
MFCD00272648
Code UNSPSC :
12161501
ID de substance PubChem :
24724644
Nomenclature NACRES :
NA.77

product name

(±)-Bufuralol hydrochloride,

Forme

solid

Couleur

white to off-white

Pf

143-146 °C

Solubilité

H2O: soluble
methanol: soluble

Température de stockage

2-8°C

Chaîne SMILES 

Cl.CCc1cccc2cc(oc12)C(O)CNC(C)(C)C

InChI

1S/C16H23NO2.ClH/c1-5-11-7-6-8-12-9-14(19-15(11)12)13(18)10-17-16(2,3)4;/h6-9,13,17-18H,5,10H2,1-4H3;1H

Clé InChI

KJBONRGCLLBWCJ-UHFFFAOYSA-N

Application

CYP2D6 substrate

Actions biochimiques/physiologiques

Bufuralol hydrochloride is known to be a non-specific β-receptor inhibitor that has an affinity for β 1 and β 2 receptors. Furthermore, studies have reported that bufuralol hydrochloride can decrease isoproterenol peripheral resistance.
β-Blocker. Varying β-adrenoceptor agonist/antagonist activity.

Caractéristiques et avantages

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Conditionnement

Bottomless glass bottle. Contents are inside inserted fused cone.

Notes préparatoires

(±)-Bufuralol hydrochloride is soluble in water and methanol.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Les clients ont également consulté

Slide 1 of 3

1 of 3

Phenacetin ≥98.0% (HPLC)

Sigma-Aldrich

77440

Phenacetin

Quinidine anhydrous

Sigma-Aldrich

Q3625

Quinidine

Coumarin ≥99% (HPLC)

Sigma-Aldrich

C4261

Coumarin

D Magometschnigg et al.
International journal of clinical pharmacology and biopharmacy, 17(11), 429-432 (1979-11-01)
In this hemodynamic study a new beta-receptor blocker, Bufuralol-hydrochloride was compared with Pindolol under an Isoproterenol infusion with increasing doses in healthy male volunteers. We found the following results: 1. Before Isoproterenol peripheral resistance increased after acute i.v. application of
Jialin Mao et al.
Drug metabolism and disposition: the biological fate of chemicals, 40(4), 706-716 (2012-01-10)
Cryopreserved human hepatocytes suspended in human plasma (HHSHP) have previously provided accurate CYP3A drug-drug interaction (DDI) predictions from a single IC(50) that captures both reversible and time-dependent inhibition. The goal of this study was to compare the accuracy of DDI
Sami Haddad et al.
Journal of pharmaceutical sciences, 99(10), 4406-4426 (2010-03-24)
Drug-drug interactions (DDIs) are a great concern to the selection of new drug candidates. While in vitro screening assays for DDI are a routine procedure in preclinical research, their interpretation and relevance for the in vivo situation still represent a
Kazuhide Iwasaki et al.
Drug metabolism and pharmacokinetics, 25(4), 388-391 (2010-09-04)
Drug metabolizing activities of cytochromes P450 (P450s, or CYPs) 3A4 and 3A5 in liver microsomes from the cynomolgus monkey [Macaca fascicularis (mf)] were investigated and compared with those of human P450 3A enzymes. Low activities for dealkylation of ethoxyresorufin and
Yasuhiro Uno et al.
Drug metabolism and disposition: the biological fate of chemicals, 38(9), 1486-1492 (2010-05-27)
The cynomolgus monkey is used in drug metabolism studies, because of its evolutionary closeness to human, including cytochrome P450. Cynomolgus monkey CYP2D17, highly homologous to human CYP2D6, has been identified and characterized. Here, we report characterization of another CYP2D, CYP2D44
Afficher tous les articles scientifiques apparentés

Articles

Discover Bioactive Small Molecules for ADME/Tox

Discover Bioactive Small Molecules for ADME/Tox

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique