UC167

Oxidized Nifedipine

powder, ~95% (HPLC)

• Synonyme(s) : 2,6-Dimethyl-4-(2´-nitrophenyl)-3,5-pyridinecarboxylic acid dimethyl ester
• Formule empirique (notation de Hill): C₁₇H₁₆N₂O₆
• Numéro CAS: 67035-22-7
• Poids moléculaire : 344.32
• Numéro MDL: MFCD00153847
• Code UNSPSC : 12161501
• ID de substance PubChem : 329827652
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ~95% (HPLC)
• Forme: powder
• Couleur: yellow
• Pf: 100-105 °C
• Température de stockage: 2-8°C
• Chaîne SMILES: COC(=O)c1c(C)nc(C)c(C(=O)OC)c1-c2ccccc2[N+]([O-])=O
• InChI: 1S/C17H16N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8H,1-4H3
• Clé InChI: UMQHJQGNGLQJPF-UHFFFAOYSA-N

Description

Application

Oxidized Nifedipine may be used:

• to study enzyme kinetics using UV high-performance liquid chromatography (UV-HPLC)
• as a standard in calibration curve preparation in high-performance liquid chromatography (HPLC) for the quantification of cytochrome P450 3A4 (CYP3A4)-mediated nifedipine oxidation in human microsomes
• in nifedipine metabolism activity assay of Hep G2 cells transfected with hepatocyte nuclear factor-1α(HNF1α)

Oxidized nifedipine has been used for apoptotic signaling studies in dopaminergic neurons.

Actions biochimiques/physiologiques

Nifedipine is a dihydropyridine derivative and a calcium channel blocker. It is used in treating hypertension and angina pectoris. Oxidized Nifedipine is an oxidation product of nifedipine generated either by exposure to UV or day light. The enzyme cytochrome P450 3A (CYP3A4) metabolizes nifedipine.

CYP3A4 nifedipine metabolite. Nifedipine (parent compound) is an antianginal and antihypertensive agent.

Conditionnement

Bottomless glass bottle. Contents are inside inserted fused cone.

Informations sur la sécurité

• Pictogrammes: GHS05
• Mention d'avertissement: Danger
• Mentions de danger: H318
• Conseils de prudence: P280 - P305 + P351 + P338
• Classification des risques: Eye Dam. 1
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves