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T5567

Monoclonal Anti-TCF-1 (T-Cell Factor-1) antibody produced in mouse

Name: Monoclonal Anti-TCF-1 (T-Cell Factor-1) antibody produced in mouse
Brand: SIGMA

~1 mg/mL, clone 7H3, purified immunoglobulin, buffered aqueous glycerol solution

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About This Item

Numéro MDL:

MFCD02686647

Code UNSPSC :

12352203

Nomenclature NACRES :

NA.41

Source biologique

mouse

Conjugué

unconjugated

Forme d'anticorps

purified immunoglobulin

Type de produit anticorps

primary antibodies

Clone

7H3, monoclonal

Forme

buffered aqueous glycerol solution

Poids mol.

antigen 26-48 kDa (32, 38, 42)

Espèces réactives

human

Concentration

~1 mg/mL

Technique(s)

immunohistochemistry (frozen sections): suitable
immunoprecipitation (IP): suitable
western blot: 0.5-2 μg/mL using whole extracts of Jurkat cells

Isotype

IgG

Numéro d'accès UniProt

P20823

Conditions d'expédition

wet ice

Température de stockage

−20°C

Informations sur le gène

human ... HNF1A(6927)

Immunogène

MBP fusion protein corresponding to amino acids 109-269 of human TCF-1A splice variant.

Forme physique

Solution in 0.1 M tris-glycine, pH 7.4, containing 0.15 M sodium chloride, 30% glycerol and 0.08% sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Certificats d'analyse (COA)

Lot/Batch Number

067K1374

120K0317

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Ectopic activation of lymphoid high mobility group-box transcription factor TCF-1 and overexpression in colorectal cancer cells.

K Mayer et al.

International journal of cancer, 72(4), 625-630 (1997-08-07)

Physical interaction between the lymphoid high mobility group (HMG)-box architectural transcription factors TCF/LEF and beta-catenin is associated with translocation of the heteromeric complex to the nucleus and regulation of target gene expression. Since formation of molecular complexes among beta-catenin, E-cadherin

The human TCF-1 gene encodes a nuclear DNA-binding protein uniquely expressed in normal and neoplastic T-lineage lymphocytes.

J Castrop et al.

Blood, 86(8), 3050-3059 (1995-10-15)

The TCF-1 gene encodes a putative transcription factor with affinity for a sequence motif occurring in a number of T-cell enhancers. TCF-1 mRNA was originally found to be expressed in a T cell-specific fashion within a set of human and

Tcf-1-mediated transcription in T lymphocytes: differential role for glycogen synthase kinase-3 in fibroblasts and T cells.

F J Staal et al.

International immunology, 11(3), 317-323 (1999-04-30)

Beta-catenin is the vertebrate homolog of the Drosophila segment polarity gene Armadillo and plays roles in both cell-cell adhesion and transduction of the Wnt signaling cascade. Recently, members of the Lef/Tcf transcription factor family have been identified as protein partners

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