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T5067

Anti-TRPC3 antibody produced in rabbit

Name: Anti-TRPC3 antibody produced in rabbit
Brand: SIGMA

affinity isolated antibody, lyophilized powder

Synonyme(s) :

Anti-Transient receptor potential cation channel, subfamily C, member 3

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About This Item

Numéro MDL:

MFCD02686005

Code UNSPSC :

12352203

Nomenclature NACRES :

NA.41

Source biologique

rabbit

Niveau de qualité

200

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

lyophilized powder

Espèces réactives

rat

Concentration

≥0.6 mg/mL (after reconstitution)

Technique(s)

western blot: suitable

Numéro d'accès UniProt

Q9JMI9

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

mouse ... Trpc3(22065)
rat ... Trpc3(60395)

Description générale

Transient receptor potential-canonical 3 (TRPC3) is a member of TRP superfamily. It is mainly expressed in brain. The TRPC3 gene is mapped to human chromosome 4.

Immunogène

peptide corresponding to amino acid residues 822-835 of mouse TRPC3.

Actions biochimiques/physiologiques

TRPC3 (transient receptor potential-canonical 3) participates in motility and capacitation of sperm. It is responsible for the proliferation of ovarian cancer cell in vitro and in vivo. TRPC3 plays a key role in a wide spectrum of Ca²⁺ signaling mechanisms. Elevated expression of TRPC3 has been observed in spontaneously hypertensive rats (SHR).

Forme physique

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, and 0.05% sodium azide

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Genotype of an individual single nucleotide polymorphism regulates DNA methylation at the TRPC3 alternative promoter.

Martin-Trujillo A

Epigenetics, 6, 1236-1241 (2011)

TRPC3: A Multifunctional Signaling Molecule

Lichtenegger M and Groschner K

Handbook of Experimental Pharmacology, 67-84 (2014)

Follicle-stimulating hormone enhances the proliferation of ovarian cancer cells by activating transient receptor potential channel C3

Tao X

Endocrine-Related Cancer, 20, 415-429 (2013)

Left Ventricular Hypertrophy Increases Susceptibility to Bupivacaine-induced Cardiotoxicity through Overexpression of Transient Receptor Potential Canonical Channels in Rats.

Hideki Hino et al.

Anesthesiology, 133(5), 1077-1092 (2020-09-12)

Local anesthetics, particularly potent long acting ones such as bupivacaine, can cause cardiotoxicity by inhibiting sodium ion channels; however, the impact of left ventricular hypertrophy on the cardiotoxicity and the underlying mechanisms remain undetermined. Transient receptor potential canonical (TRPC) channels

Increased Transient Receptor Potential Channel TRPC3 Expression in Spontaneously Hypertensive Rats

Liu D

American Journal of Hypertension, 18, 1503-1507 (2005)

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