T4442
Anti-Transforming Growth Factor-β2 antibody produced in goat
affinity isolated antibody, lyophilized powder
Synonyme(s) :
Anti-TGF-β2
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About This Item
Source biologique
goat
Niveau de qualité
Conjugué
unconjugated
Forme d'anticorps
affinity isolated antibody
Type de produit anticorps
primary antibodies
Clone
polyclonal
Forme
lyophilized powder
Espèces réactives
human, pig
Technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
neutralization: suitable
western blot: 0.1-0.2 μg/mL
Numéro d'accès UniProt
Application(s)
research pathology
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... TGFB2(7042)
Description générale
Transforming Growth Factor-β 2 (TGF-β 2) is a protein produced by many cells and is found in the highest concentration in mammalian bone and porcine platelets. In body fluids like breast milk, amniotic fluid as well as the aqueous and vitreous humor of the eye, the prominent form exist is Latent TGF-β2. It has a pivotal role in regulating invasion in high-grade gliomas by inducing mesenchymal phenotype and remodeling the extracellular matrix. Anti-Transforming Growth Factor-β2 antibody can be used in neutralization and immunohistochemistry. Goat anti-TGF-β 2 antibody reacts specifically with human and porcine TGF-β 2 and TGF-β 1.2. The product has also shown less than 2% cross-reactivity for TGF-β 1, TGF-β 3 and TGF-β 5.
Spécificité
The antibody recognizes TGF-β2 and TGF-β1.2. By immunoblotting (non-reducing conditions) and ELISA, the antibody shows less than 2% cross-reactivity with TGF-β1, TGF-β3, and TGF-β5.
Immunogène
porcine transforming growth factor-β2.
Application
Anti-Transforming Growth Factor-β2 antibody can be used in western blotting and ELISA.
Forme physique
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
12 - Non Combustible Liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Elisabetta Polazzi et al.
Journal of neurochemistry, 110(2), 545-556 (2009-05-22)
Microglia, the immune cells of the CNS, play essential roles in both physiological and pathological brain states. Here we have used an in vitro model to demonstrate neuroprotection of a 48 h-microglial conditioned medium (MCM) towards cerebellar granule neurons (CGNs)
Fusun Baumann et al.
Neuro-oncology, 11(4), 368-380 (2008-11-27)
Lactate dehydrogenase type A (LDH-A) is a key metabolic enzyme catalyzing pyruvate into lactate and is excessively expressed by tumor cells. Transforming growth factor-beta2 (TGF-beta2) is a key regulator of invasion in high-grade gliomas, partially by inducing a mesenchymal phenotype
A B Roberts et al.
Molecular reproduction and development, 32(2), 91-98 (1992-06-01)
The TGF-beta's are multifunctional, pleiotropic molecules with major effects in control of cellular migration, cellular proliferation, and elaboration of extracellular matrix. Thus far, five distinct isoforms of TGF-beta have been described, each approximately 65-85% homologous and containing the characteristic 9
Lei Hong et al.
Cell death & disease, 11(8), 695-695 (2020-08-23)
Endothelial to mesenchymal transition (EndMT) is an important pathological change in many diseases. Semaphorin7A (Sema7A) has been reported to regulate nerve and vessel homeostasis, but its role in EndMT remains unclear. Here we investigate the effect of Sema7A on EndMT
Gaurav K Keshri et al.
PloS one, 11(11), e0166705-e0166705 (2016-11-20)
Chronic non-healing cutaneous wounds are often vulnerable in one or more repair phases that prevent normal healing and pose challenges to the use of conventional wound care modalities. In immunosuppressed subject, the sequential stages of healing get hampered, which may
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