T1941
Anti-TrkB antibody produced in goat
affinity isolated antibody, lyophilized powder
Synonyme(s) :
Anti-DEE58, Anti-EIEE58, Anti-GP145-TrkB, Anti-OBHD, Anti-TRKB, Anti-trk-B
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About This Item
Produits recommandés
Source biologique
goat
Niveau de qualité
Conjugué
unconjugated
Forme d'anticorps
affinity isolated antibody
Type de produit anticorps
primary antibodies
Clone
polyclonal
Forme
lyophilized powder
Espèces réactives
human
Technique(s)
flow cytometry: 2.5 μg/mL (per 106 cells)
western blot: 0.25-0.5 μg/mL
Numéro d'accès UniProt
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... NTRK2(4915)
Catégories apparentées
Description générale
The antibody recognizes recombinant human TrkB. It shows no cross-reactivity with TrkC, NT-3, NT-4, BDNF and NGF-β.
Immunogène
recombinant human TrkB extracellular domain expressed in NS0 cells.
Actions biochimiques/physiologiques
The development and maintenance of central and peripheral nervous system is controlled by a family of Trk family of neurotrophin receptors. The Trk family consists of 3 members, TrkA (NTRK1), Trk B (NTRK2) and TrkC (NTRK3). Neurotrophins have an important role in development of the nervous system and mediate the cellular effects by binding to the Trk receptors. Trk receptors reportedly play a major role in the development and behaviour of neuroblastomas and other type of cancers.
Forme physique
Lyophilized from a 0.2 μm filtered solution of phosphate buffered saline containing 5% trehalose.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Réf. du produit
Description
Tarif
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Q Liu et al.
The EMBO journal, 19(8), 1827-1838 (2000-04-25)
The TEL-TRKC fusion is expressed as a consequence of t(12;15)(p13;q25), and is associated with two human cancers: congenital fibrosarcoma and acute myelogenous leukemia (AML). We report that the T/T(F) and T/T(L) fusion variants associated with congenital fibrosarcoma and AML, respectively
Umed Boltaev et al.
Science signaling, 10(493) (2017-08-24)
Brain-derived neurotrophic factor (BDNF) and its receptor, tropomyosin-related kinase B (TrkB), have emerged as key regulators of brain plasticity and represent disease-modifying targets for several brain disorders, including Alzheimer's disease and major depressive disorder. Because of poor pharmacokinetic properties of
M Cazorla et al.
British journal of pharmacology, 162(4), 947-960 (2010-11-03)
By interacting with trkB receptors, brain-derived neurotrophic factor (BDNF) triggers various signalling pathways responsible for neurone survival, differentiation and modulation of synaptic transmission. Numerous reports have implicated BDNF and trkB in the pathogenesis of various central nervous system affections and
Garrett M Brodeur et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 15(10), 3244-3250 (2009-05-07)
Neuroblastoma, the most common and deadly solid tumor in children, exhibits heterogeneous clinical behavior, from spontaneous regression to relentless progression. Current evidence suggests that the TRK family of neurotrophin receptors plays a critical role in these diverse behaviors. Neuroblastomas expressing
Louis F Reichardt
Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 361(1473), 1545-1564 (2006-08-31)
Neurotrophins are a family of closely related proteins that were identified initially as survival factors for sensory and sympathetic neurons, and have since been shown to control many aspects of survival, development and function of neurons in both the peripheral
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