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T0410

Sigma-Aldrich

Tiapride hydrochloride

Synonyme(s) :

N-[2-(Diethylamino)ethyl]-5-(methylsulfonyl)-o-anisamide hydrochloride

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About This Item

Formule empirique (notation de Hill):
C15H24N2O4S · HCl
Numéro CAS:
51012-32-9
Poids moléculaire :
364.89
Numéro CE :
256-908-4
Numéro MDL:
MFCD00133861
Code UNSPSC :
12352200
ID de substance PubChem :
24278720

Température de stockage

2-8°C

Chaîne SMILES 

Cl.CCN(CC)CCNC(=O)c1cc(ccc1OC)S(C)(=O)=O

InChI

1S/C15H24N2O4S.ClH/c1-5-17(6-2)10-9-16-15(18)13-11-12(22(4,19)20)7-8-14(13)21-3;/h7-8,11H,5-6,9-10H2,1-4H3,(H,16,18);1H

Clé InChI

OTFDPNXIVHBTKW-UHFFFAOYSA-N

Informations sur le gène

human ... DRD2(1813) , DRD3(1814)

Application

Tiapride and inhibitor of nitric oxide synthase were coadministered to mice to study the effect of dopamine D2 transmission in catalepsy.

Actions biochimiques/physiologiques

Tiapride, an atypical neuroleptic agent, antagonizes D2 and D3 dopamine receptors. It exhibits anti-dyskinetic and anxiolytic activities. It is effective in the management of alcohol withdrawal and treatment of tic disease in children.

Code de la classe de stockage

13 - Non Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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M S Lidow et al.
The Journal of pharmacology and experimental therapeutics, 283(2), 939-946 (1997-11-14)
The RNase Protection Assay was used to examine the regulation of D2 and D4 dopamine receptor mRNAs in the cerebral cortex and neostriatum of nonhuman primates after chronic treatment with a wide spectrum of antipsychotic medications (chlorpromazine, clozapine, haloperidol, molindone
Maria Cavas et al.
Progress in neuro-psychopharmacology & biological psychiatry, 26(1), 69-73 (2002-02-21)
This study was designed to determine the possible potentiation of catalepsy behavior after coadministration of N(G)-nitro-L-arginine (L-NOARG), an inhibitor of nitric oxide synthase (NOS), and tiapride, a specific antagonist for D2 receptors, in male mice. Catalepsy was measured by the
C Eggers et al.
European archives of psychiatry and neurological sciences, 237(4), 223-229 (1988-01-01)
Tiapride, a substituted benzamide derivative, possesses good clinical antidyskinetic properties due to its DA2-blocking activities. It has been shown to be clinically effective in the treatment of tic disease in children. In order to study tiapride's antidyskinetic properties in the
C Cohen et al.
The Journal of pharmacology and experimental therapeutics, 283(2), 566-573 (1997-11-14)
The ability of tiapride, a selective D2/D3 dopamine receptor antagonist, to exert discriminative stimulus control of responding was investigated by training rats to discriminate this drug (30 mg/kg) from saline in a two-lever, food-reinforcement procedure. Acquisition of tiapride discrimination required
D H Peters et al.
Drugs, 47(6), 1010-1032 (1994-06-01)
Tiapride, an atypical neuroleptic agent, is a selective dopamine D2-receptor antagonist with little propensity for causing catalepsy and sedation. It shows preferential activity at receptors previously sensitised to dopamine and those located extrastriatally. Tiapride demonstrates antidyskinetic activity reflecting antidopaminergic actions
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