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SRP6543

Sigma-Aldrich

Netrin-1 human

recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

Synonyme(s) :

NTN1

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About This Item

Code UNSPSC :
12352200
Nomenclature NACRES :
NA.32

Source biologique

human

Produit recombinant

expressed in HEK 293 cells

Pureté

≥95% (SDS-PAGE)

Forme

lyophilized

Poids mol.

~800 kDa (Human netrin-1 aa 25-604 is fused at the C-terminus to a FLAG0174-tag.)

Conditionnement

pkg of 10 μg

Impuretés

<0.1 EU/μg endotoxin (LAL test)

Numéro d'accès UniProt

O95631

Conditions d'expédition

wet ice

Température de stockage

−20°C

Informations sur le gène

human ... NTN1(9423)

Description générale

Netrin-1 controls guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Netrin-1 is also Involved in tumorigenesis by regulating apoptosis.

Forme physique

Lyophilized in PBS with trehalose and Brij 35.

Reconstitution

Reconstitute with 100 μsterile distilled water.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Jinyuan Li et al.
Neuroscience letters, 735, 135161-135161 (2020-06-20)
The burden of neuropathic pain is growing worldwide. Recent studies recapitulate the requirement for AMPA receptor in excitatory synaptic plasticity underlying pain-related syndromes. Netrin-1 and its receptor deleted in colorectal cancer (DCC) are fundamental for AMPA receptor dependent synaptic transmission.
Xinyue Guo et al.
International journal of biological macromolecules, 148, 226-237 (2020-01-19)
Netrin-1 is an extracellular guidance cue of neuronal navigation, mediated through interaction with its main receptors, and is known to be crucial in the development of multiple chronic inflammatory diseases. However, the expression pattern and mechanism of netrin-1 in endometriosis
Tracy S Tran et al.
Neural development, 8, 15-15 (2013-08-02)
Spinal commissural axons represent a model system for deciphering the molecular logic that regulates the guidance of midline-crossing axons in the developing central nervous system (CNS). Whether the same or specific sets of guidance signals control the navigation of molecularly
Valbona Mirakaj et al.
The Journal of experimental medicine, 211(6), 1037-1048 (2014-05-28)
Resolution of inflammation is now recognized as a biosynthetically active process involving pro-resolving mediators. Here, we show in zymosan-initiated peritoneal inflammation that the vagus nerve regulates local expression of netrin-1, an axonal guidance molecule that activates resolution, and that vagotomy
Joo In Park et al.
Journal of Korean medical science, 22(4), 641-645 (2007-08-31)
Netrin is a neuronal guidance molecule implicated in the development of spinal commissural neurons and cortical neurons. The attractive function of netrin requires the receptor, Deleted in Colorectal Cancer (DCC), while the receptor Unc5h is involved in the repulsive action
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