SRP6537

Lipocalin-2/LCN2 from mouse

recombinant, expressed in HEK 293 cells, ≥90% (SDS-PAGE)

• Synonyme(s) : 24p3, MSFI, NGAL, Neutrophil Gelatinase-associated Lipocalin, Oncogene 24p3, Siderocalin
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.32

Propriétés

• Source biologique: mouse
• Produit recombinant: expressed in HEK 293 cells
• Essai: ≥90% (SDS-PAGE)
• Forme: liquid
• Poids mol.: monomer ~250 kDa (Mouse lipocalin-2 aa 1-200 is fused at the C-terminus to a FLAG0174-tag.)
• Conditionnement: pkg of 10 and 50 μg
• Impuretés: <0.1 EU/μg endotoxin (LAL test)
• Numéro d'accès UniProt: P11672
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Informations sur le gène: mouse ... LCN2(16819)

Description

Description générale

LCN2 (lipocalin-2), a secreted glycoprotein is an adipokine.[1][2] It is expressed in various cells like respiratory and intestinal epithelial cells, endothelial cells, renal tubular cells and cardiomyocytes.[3] The gene LCN2 is located on human chromosome 9q34.[4]

Lipocalin-2 (LCN2), also known as oncogene 24p3 or neutrophil gelatinase-associated lipocalin (NGAL), MSFI, The binding of lipocalin-2 to bacterial siderophores is important in the innate immune response to bacterial infection. Upon encountering invading bacteria the toll-like receptors on immune cells stimulate the synthesis and secretion of lipocalin-2. Secreted lipocalin-2 then limits bacterial growth by sequestering iron-containing siderophores. Lipocalin-2 also functions as a growth factor. LCN2 is strongly upregulated during inflammation and is upregulated by interleukin 1 (but not TNF α) in humans. There are indications that some forms of acne could be caused due to the gene not being transcribed, and that Isotretinoin corrects this. NFAT3 (NFATc4) NFAT by blocking the expression of LCN2 inhibits breast carcinoma cell motility. Recent studies have revealed that NGAL plays an important role in the physiopathology of chronic myeloid leukaemia (CML) mediated by BCR-ABL.

Actions biochimiques/physiologiques

LCN2 (lipocalin-2) has also been implicated in a variety of processes including cell differentiation, tumorigenesis, and apoptosis.[3] Polymorphisms in the expression of LCN2 are associated with many cancers such as breast, colorectal, pancreatic, ovarian, gastric, thyroid, ovarian, bladder and kidney cancers.[1]

Forme physique

0.2 μm-filtered solution in PBS.

Informations sur la sécurité

• Code de la classe de stockage: 13 - Non Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable