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SRP5194

I?Bα, GST tagged human

Name: I?Bα, GST tagged human
Brand: SIGMA

recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonyme(s) :

MAD-3, NFKBI, NFKBIA

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About This Item

Code UNSPSC :

12352202

Nomenclature NACRES :

NA.32

Produit recombinant

expressed in E. coli

Pureté

≥70% (SDS-PAGE)

Forme

buffered aqueous glycerol solution

Poids mol.

~61 kDa

Numéro d'accès NCBI

NM_020529

Conditions d'expédition

dry ice

Température de stockage

−70°C

Informations sur le gène

human ... NFKBIA(4792)

Description générale

IκBα is an inhibitor of the NFκB complex and inactivates the NFκB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IκB protein by IκB kinases (IKKs) marks it for destruction via the ubiquitination pathway, thereby allowing the activation of the NFκB complex. Synthetic glucocorticoid such as dexamethasone display anti-inflammatory effects by inducing the increased synthesis of the IκB protein thereby inhibiting the activity of the NFκB complex. Overexpression of the IκBα gene in fibroblasts leads to inhibition of production of IL-6, TNF receptor, MMP-1, MMP-3 and MMP-13.

Forme physique

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Notes préparatoires

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Adenoviral gene transfer of the endogenous inhibitor IkappaBalpha into human osteoarthritis synovial fibroblasts demonstrates that several matrix metalloproteinases and aggrecanases are nuclear factor-kappaB-dependent.

Jan Bondeson et al.

The Journal of rheumatology, 34(3), 523-533 (2007-02-14)

To investigate the role of the transcription factor nuclear factor-kB (NF-kappaB) in promoting inflammatory and destructive responses in human osteoarthritis (OA) synovial fibroblasts, by assessing the effect of NF-kappaB blockade on the production of cytokines and destructive enzymes. Infection with

Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis.

N Auphan et al.

Science (New York, N.Y.), 270(5234), 286-290 (1995-10-13)

Glucocorticoids are among the most potent anti-inflammatory and immunosuppressive agents. They inhibit synthesis of almost all known cytokines and of several cell surface molecules required for immune function, but the mechanism underlying this activity has been unclear. Here it is

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