SML3997

FOY-251 mesylate

≥98% (HPLC)

• Synonyme(s) : 4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]-benzeneacetic acid, methanesulfonate; 4-(4-Guanidinobenzoyloxy)phenylacetic acid, methanesulfonate, CC6 mesylate salt, Camostat active metabolite, FOY 251 mesylate salt, FOY 305 active metabolite, FOY-305 active metabolite, FOY251 mesylate salt, GBPA mesylate salt
• Formule empirique (notation de Hill): C₁₆H₁₅N₃O₄·CH₄O₃S
• Numéro CAS: 71079-09-9
• Poids moléculaire : 409.41
• Numéro MDL: MFCD09842546
• Code UNSPSC : 51111800
• Code UNSPSC : 12352200

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated
• Couleur: white to beige
• Solubilité: DMSO: 2 mg/mL, clear (warmed)
• Température de stockage: 2-8°C
• Chaîne SMILES: O=C(C1=CC=C(NC(N)=N)C=C1)OC2=CC=C(CC(O)=O)C=C2.O=S(O)(C)=O
• Clé InChI: JXMOPIDYHUYOED-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

Trypsin-like serine protease inhibitor Camostat (FOY-305) active metabolite with inhibitory potency against transmembrane serine protease 2 (TMPRSS2).



FOY-251 is a trypsin-like serine protease inhibitor and an active metabolite of the oral drug Camostat/FOY-305 (trypsin IC50 = 51/55 nM by FOY-305/FOY-251; plasma kallikrein/plasmin IC50 = 1.48/2.64 μM by FOY-305 and 2.32/12.5 μM by FOY-251). FOY-251 and FOY-305 are also potent inhibitor against transmembrane serine protease 2 (TMPRSS2 IC50 = 6.2/33.3 nM by by FOY-305/FOY-251) that primes SARS-CoV-2 spike protein for host cell entry.

Attention

Hygroscopic

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302,H315
• Conseils de prudence: P264 - P280 - P301 + P312 - P302 + P352 - P332 + P313 - P362 + P364
• Classification des risques: Acute Tox. 4 Oral - Skin Irrit. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable