IAXO-102 is a potent and selective toll-like receptor 4 (TLR4) antagonist that protect mice from LPS induced septic shock. IAXO-102 inhibits development of an experimental abdominal aortic aneurysm. It also prevents acute BBB disruption after experimental post-subarachnoid hemorrhage in mice.
Potent and selective toll-like receptor 4 (TLR4) antagonist that protect mice from LPS induced septic shock.
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Faites votre choix parmi les versions les plus récentes :
A novel small molecule TLR4 antagonist (IAXO-102) negatively regulates non-hematopoietic toll like receptor 4 signalling and inhibits aortic aneurysms development.
Huggins C, Pearce S, Peri F, Neumann F, Cockerill G, Pirianov G.
Atherosclerosis (2015)
Glycolipids and benzylammonium lipids as novel antisepsis agents: synthesis and biological characterization.
Piazza M, Rossini C, Della Fiorentina S, Pozzi C, Comelli F, Bettoni I, Fusi P, Costa B, Peri F.
Journal of Medicinal Chemistry (2009)
Selective Toll-Like Receptor 4 Antagonists Prevent Acute Blood-Brain Barrier Disruption After Subarachnoid Hemorrhage in Mice.
Okada T, Kawakita F, Nishikawa H, Nakano F, Liu L, Suzuki H.
Molecular Neurobiology (2019)
Questions
Reviews
★★★★★ No rating value
Active Filters
Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..