SML3223

CAY10566

≥98% (HPLC)

• Synonyme(s) : 2-(6-(4-(2-Chloro-5-fluorophenoxy)piperidin-1-yl)pyridazin-3-yl)-5-methyl-1,3,4-oxadiazole, Abbott compound 74, Abbott-28c, CAY 10566, CAY-10566, SCD1 inhibitor 28c
• Formule empirique (notation de Hill) : C₁₈H₁₇ClFN₅O₂
• Numéro CAS: 944808-88-2
• Poids moléculaire : 389.81
• Numéro MDL: MFCD11976899
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: off-white to orange
• Solubilité: DMSO: 2 mg/mL, clear (warmed)
• Température de stockage: 2-8°C
• Chaîne SMILES: Fc1cc(c(cc1)Cl)OC2CCN(CC2)c3nnc(cc3)c4nnc([o]4)C
• InChI: 1S/C18H17ClFN5O2/c1-11-21-24-18(26-11)15-4-5-17(23-22-15)25-8-6-13(7-9-25)27-16-10-12(20)2-3-14(16)19/h2-5,10,13H,6-9H2,1H3
• Clé InChI: WFOFPVXMPTVOTJ-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

CAY10566 is a potent and selective stearoyl-CoA desaturase 1 (SCD1) inhibitor (IC50 = 26 nM/hSCD1 and 4.5 nM/mSCD1; IC50 >10 μM/75 receptors, transporters, ion channels). CAY10566 effectively blocks the conversion of saturated long-chain fatty acid-CoAs (LCFA-CoAs) to monounsaturated LCFA-CoAs in HepG2 cells (IC50 = 7.9 nM by C17:1/C17:0 ratio; IC50 = 6.8 nM by C16:1/C16:0 ratio) and exhibits good metabolic stability (by rat & mouse liver microsome assays) and oral availability (rat F = 59.2%; 5 mg/kg p.o.). CAY10566 is typically used in the range from 0.1-10 μM for cell treatment.

Orally available, potent and selective stearoyl-CoA desaturase 1 (SCD1) inhibitor.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable