SML1778

SR0987

≥98% (HPLC)

• Synonyme(s) : 2-Chloro-N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxy-2-propanyl)phenyl)benzamide
• Formule empirique (notation de Hill): C₁₆H₁₀ClF₆NO₂
• Numéro CAS: 303126-97-8
• Poids moléculaire : 397.70
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: 20 mg/mL, clear
• Température de stockage: −20°C
• Chaîne SMILES: FC(F)(F)C(O)(C(F)(F)F)c1ccc(cc1)NC(=O)c2c(cccc2)Cl
• Clé InChI: IZVBONMVWLTLNT-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

SR0987 is a cell-permeable SR1078 analog with ~6-fold improved agonist potency toward T-cell-specific retinoic acid receptor-related orphan receptor ROR?t (EC₅₀ ~800 nM in cell-based reporter assays) by targeting an allosteric pocket within the RORγt ligand-binding domain (LBD). In addition to upregulating RORγt target gene IL17A expression, SR0987 is shown to simultaneously downregulate surface immune checkpoint protein PD-1 expression by a yet unidentified mechanism among ex vivo differentiated murine TH17 cells, as well as PMA/ionophore-stimulated human Jurkat T cells and murine EL4 T lymphocytes.

SR0987 is a cell-permeable SR1078 analog with ~6-fold improved agonist potency.

Informations sur la sécurité

• Pictogrammes: GHS07,GHS09
• Mention d'avertissement: Warning
• Mentions de danger: H302,H410
• Conseils de prudence: P264 - P270 - P273 - P301 + P312 - P391 - P501
• Classification des risques: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable