SML0899

Windorphen

≥98% (HPLC)

• Synonyme(s) : (Z)-3-Chloro-2,3-bis(4-methoxyphenyl)acrylaldehyde
• Formule empirique (notation de Hill): C₁₇H₁₅ClO₃
• Numéro CAS: 19881-70-0
• Poids moléculaire : 302.75
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: protect from light
• Couleur: white to beige
• Solubilité: DMSO: 5 mg/mL, clear (warmed)
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• InChI: 1S/C17H15ClO3/c1-20-14-7-3-12(4-8-14)16(11-19)17(18)13-5-9-15(21-2)10-6-13/h3-11H,1-2H3/b17-16-
• Clé InChI: VNRALGZMXHFBPG-MSUUIHNZSA-N

Description

Actions biochimiques/physiologiques

Windorphen is a selective Wnt/β-catenin signaling inhibitor acting through selective inhibition of p300, a histone acetyltransferase (HAT) that also acts as a critical coactivator of β-catenin, a transcription factor that mediates the Wnt signaling pathway involved in embryogenesis and cancer cell survival. Windorphen blocks Wnt signaling by selectively disrupting the association of p300 with the C-terminal transactivation domain of β-catenin-1. Windorphen does not inhibit the closely related CREB-binding protein (CBP). Windorphen induced apoptosis in several Wnt-dependent tumor cell lines including colon adenocarcinoma SW480and RKO and prostate cancer cell lines DU145 and PC3.

Caractéristiques et avantages

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Autres remarques

Light sensitive

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable