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SCP0148

Sigma-Aldrich

Furin Inhibitor II Peptide

≥95% (HPLC), lyophilized powder

Synonyme(s) :

Hexa-D-arginine amide

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About This Item

Formule empirique (notation de Hill) :
C36H75N25O6
Poids moléculaire :
954.14
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.32

270,00 €

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Nom du produit

Furin Inhibitor II,

Essai

≥95% (HPLC)

Forme

lyophilized

Composition

Peptide Content, ≥48%

Conditions de stockage

protect from light

Technique(s)

protein extraction: suitable

Température de stockage

−20°C

Amino Acid Sequence

Mpa-Mpa-Mpa-Mpa-Mpa-Mpa

Description générale

Furin is a calcium-dependent serine endoproteinase and belongs to the subtilisin-like proprotein/prohormone convertase (PC) family.[1] It is distributed ubiquitously and has a rhythmic movement between the trans-Golgi network, cell surface and the endosomes.[1]

Application

Furin Inhibitor II has been used as a furin inhibitor:
  • to study its effects on transforming growth factor β1 (TGF-β1) induced glial cell line-derived neurotrophic factor (GDNF) production in non-tumorigenic immortalized human granulosa cell line (SVOG).[2]
  • to study its effect on cleavage of (Pro) renin receptor (PRR) induced by bovine serum albumin (BSA) in human kidney 2 (HK-2) cells.[3]
  • in furin cleavage assay.[4]

Actions biochimiques/physiologiques

Furin plays a role in processing several pro-proteins such as, bone morphogenetic protein 4 (BMP-4), insulin receptor and Notch1 receptor. It also processes human immune deficiency virus 1 (HIV-1) glycoprotein gp160, several metalloproteases and pro-β-nerve growth (pro-β-NGF) factor. Furin is also involved in cleaving transforming growth factor β1 (TGF-β1).[5]

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
E278093
E257140
E1094
MI1170

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Batimastat ≥98% (HPLC)

Sigma-Aldrich

SML0041

Batimastat

Poly-L-arginine hydrochloride mol wt 15,000-70,000

Sigma-Aldrich

P7762

Poly-L-arginine hydrochloride

Evidence that furin is an authentic transforming growth factor-beta1-converting enzyme
Dubois C M, et al.
The American Journal of Pathology, 158(1), 305-316 (2001)
A Cameron et al.
The Journal of biological chemistry, 275(47), 36741-36749 (2000-08-26)
The ubiquitous serine endoprotease furin has been implicated in the activation of bacterial toxins and viral glycoproteins as well as in the metastatic progression of certain tumors. Although high molecular mass bioengineered serpin inhibitors have been well characterized, no small
Miroslav S Sarac et al.
Infection and immunity, 70(12), 7136-7139 (2002-11-20)
The Pseudomonas aeruginosa exotoxin A (PEA) protein requires furin-mediated cleavage for manifestation of toxicity. We show here that the small stable furin inhibitor hexa-D-arginine amide effectively blocks PEA-induced cell lysis and is itself noncytotoxic. Administration of hexa-D-arginine to PEA-treated mice
Marcel Westenberg et al.
Journal of virology, 76(1), 178-184 (2001-12-12)
The Spodoptera exigua multicapsid nucleopolyhedrovirus (SeMNPV) Se8 gene was recently shown to encode the viral envelope fusion (F) protein. A 60-kDa C-terminal subunit (F1) of the 76-kDa primary translation product of this gene was found to be the major envelope
Miroslav S Sarac et al.
Infection and immunity, 72(1), 602-605 (2003-12-23)
The anthrax toxin protective antigen precursor is activated by proteolytic cleavage by furin or a furin-like protease. We present here data demonstrating that the small stable furin inhibitor hexa-D-arginine amide delays anthrax toxin-induced toxemia both in cells and in live
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Questions

1–3 of 3 Questions  

  1. How can product SCP0148, Furin Inhibitor II, be dissolved?

    1 answer

    1. Product SCP0148, Furin Inhibitor II is soluble in water at 1 mg/ml.

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  2. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  3. How can Product SCP0148, Furin Inhibitor II be dissolved?

    1 answer

    1. Product SCP0148, Furin Inhibitor II, is soluble in water at a concentration of 1 mg/mL.

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