SBR00037

Solithromycin

≥98% (HPLC)

• Synonyme(s) : 2H-Oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone, CEM-101, OP-1068
• Formule empirique (notation de Hill) : C₄₃H₆₅FN₆O₁₀
• Poids moléculaire : 845.01
• Numéro MDL: MFCD30207880
• Code UNSPSC : 51102829
• Nomenclature NACRES : NA.76

Propriétés

• Niveau de qualité: 200
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white to off-white
• Spectre d'activité de l'antibiotique: Gram-negative bacteria; Gram-positive bacteria
• Mode d’action: protein synthesis | interferes
• Température de stockage: −20°C
• Chaîne SMILES: F[C@@]1(C(=O)O[C@@H]([C@]2(OC(=O)N([C@@H]2[C@H](C(=O)[C@@H](C[C@]([C@@H]([C@H](C1=O)C)O[C@@H]5O[C@@H](C[C@@H]([C@H]5O)N(C)C)C)(OC)C)C)C)CCCC[n]3nnc(c3)c4cc(ccc4)N)C)CC)C
• InChI: 1S/C43H65FN6O10/c1-12-32-43(8)35(50(40(55)60-43)19-14-13-18-49-23-30(46-47-49)28-16-15-17-29(45)21-28)26(4)33(51)24(2)22-41(6,56-11)37(27(5)36(53)42(7,44)39(54)58-32)59-38-34(52)31(48(9)10)20-25(3)57-38/h15-17,21,23-27,31-32,34-35,37-38,52H,12-14,18-20,22,45H2,1-11H3/t24-,25-,26+,27+,31+,32-,34-,35-,37-,38+,41-,42+,43-/m1/s1
• Clé InChI: IXXFZUPTQVDPPK-ZAWHAJPISA-N

Description

Description générale

Solithromycin is a highly potent next-generation macrolid. the first fluoroketolid. which has potent activity against most macrolide-resistant strains. Solithromycin (CEM-101) is a novel fluoroketolide with improved antimicrobial effectiveness.

Application

Solithromycin has been shown to have potentent activity against S. pneumoniae as well as an extended spectrum of activity against CA-MRS. enterococc according to in vitro and in vivo research. Solithromycin has been used in:

• the research on the anti-inflammatory effects of macrolides[1]
• the research of potency of solithromycin in comparison to other antimicrobials[2]
• in ithe research of the vitro activity of solithromycin against clinical N. gonorrhoeae isolates and reference strain[3]

Actions biochimiques/physiologiques

Mode of Action: Solithromycin binds to the large 50S subunit of the ribosome and inhibits protein biosynthesis. Like other ketolide. it should impair bacterial ribosomal subunit formation.

Antimicrobial spectrum: Active against bacteria like Legionella, Chlamydophila, Chlamydia, Mycoplasma, and Ureaplasma and against gonococci and other organisms that cause genitourinary tract infections

Caractéristiques et avantages

High quality antibiotic suitable for mulitple research applications

Autres remarques

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Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable