SAB5700323

Anti-Phospho-RB-S795 antibody produced in rabbit

• Synonyme(s) : OSRC, PPP1R130, RB, RB1, Rb, p105-Rb, pRb, pp110
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 100
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: buffered aqueous solution
• Poids mol.: 106
• Espèces réactives: human
• Concentration: 0.52 mg/ml
• Technique(s): immunofluorescence: 1:50-1:100; western blot: 1:500-1:1000
• Numéro d'accès UniProt: P06400
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: phosphorylation (pSer795)
• Informations sur le gène: human ... RB1(5925)

Description

Description générale

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

Immunogène

A synthetic phosphorylated peptide around S795 of human RB (NP_000312.2).

Forme physique

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Stockage et stabilité

Store at -20℃. Avoid freeze / thaw cycles.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable