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Key Documents

COO/COA

SAB5300353

Monoclonal Anti-CASP8 antibody produced in mouse

Name: Monoclonal Anti-CASP8 antibody produced in mouse
Brand: SIGMA

clone 1H11, ascites fluid

Synonyme(s) :

ALPS2B, CAP4, FLICE, MACH, MCH5

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About This Item

Code UNSPSC :

12352203

Nomenclature NACRES :

NA.41

Source biologique

mouse

Conjugué

unconjugated

Forme d'anticorps

ascites fluid

Type de produit anticorps

primary antibodies

Clone

1H11, monoclonal

Poids mol.

26 kDa

Espèces réactives

human, mouse, rat, monkey

Technique(s)

direct ELISA: 1:10,000
flow cytometry: 1:200-1:400
immunohistochemistry: 1:200-1:1,000
western blot: 1:500-1:2,000

Isotype

IgG1

Numéro d'accès NCBI

NM_001080124

Numéro d'accès UniProt

Q14790

Conditions d'expédition

wet ice

Température de stockage

−20°C

Informations sur le gène

human ... CASP8(841)

Immunogène

Purified recombinant fragment of human CASP8 expressed in E.coli.
Mouse monoclonal antibody raised against CASP8

Forme physique

Ascitic fluid containing 0.03% sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Ultrasound-targeted microbubble destruction combined with dual targeting of HSP72 and HSC70 inhibits HSP90 function and induces extensive tumor-speciﬁc apoptosis.

Hanghui Wang et al.

International journal of oncology, 45(1), 157-164 (2014-04-17)

The specific and efficient delivery of small interfering RNA (siRNA) into cancer cells in vivo remains a major obstacle. In this study, we investigated whether ultrasound-targeted microbubble destruction (UTMD) combined with dual targeting of HSP72 and HSC70 in prostate cancer cell

Caspase-8 mutations in head and neck cancer confer resistance to death receptor-mediated apoptosis and enhance migration, invasion, and tumor growth.

Changyou Li et al.

Molecular oncology, 8(7), 1220-1230 (2014-05-13)

Little is known regarding molecular markers in head and neck squamous cell carcinoma (HNSCC) that predict responsiveness to different therapeutic regimens or predict HNSCC progression. Mutations in procaspase-8 occur in 9% of HNSCC primary tumors, but the functional consequences of

Mitochondria autophagy is induced after hypoxic/ischemic stress in a Drp1 dependent manner: the role of inhibition of Drp1 in ischemic brain damage.

Wei Zuo et al.

Neuropharmacology, 86, 103-115 (2014-07-16)

Mitochondria dysfunction is implicated in diverse conditions, including metabolic and neurodegenerative disorders. Mitochondrial dynamics has attracted increasing attention as to its relationship with mitochondria autophagy, also known as mitophagy, which is critical for degradation of dysfunctional mitochondria maintaining mitochondrial homeostasis.

Chemosensitization of rhabdomyosarcoma cells by the histone deacetylase inhibitor SAHA.

Ulrike Heinicke et al.

Cancer letters, 351(1), 50-58 (2014-05-13)

Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in childhood with a dismal prognosis, highlighting the need for novel treatment strategies. Here, we identify a novel synthetic lethal interaction between the histone deacetylase inhibitor (HDACI) SAHA and anticancer drugs in

Identification of novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening.

Sireesha V Garimella et al.

Breast cancer research : BCR, 16(2), R41-R41 (2014-04-22)

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) binds to its receptors, TRAIL-receptor 1 (TRAIL-R1) and TRAIL-receptor 2 (TRAIL-R2), leading to apoptosis by activation of caspase-8 and the downstream executioner caspases, caspase-3 and caspase-7 (caspase-3/7). Triple-negative breast cancer (TNBC) cell lines with

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