SAB5200113

Anti-APP antibody produced in rabbit

1 mg/mL, affinity isolated antibody

• Synonyme(s) : Anti-A11, Anti-Amyloid Oligomer αβ, Anti-Amyloid Oligomers (A11)
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Conjugué: unconjugated
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: buffered aqueous glycerol solution
• Espèces réactives: mouse, eukaryotes, rat, human
• Concentration: 1 mg/mL
• Technique(s): immunohistochemistry: suitable; immunoprecipitation (IP): suitable; indirect ELISA: suitable; indirect immunofluorescence: suitable; western blot: suitable
• Numéro d'accès NCBI: NM_000484.2
• Numéro d'accès UniProt: P05067
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... APP(351)

Description

Description générale

Amyloid β precursor protein (APP) is a type 1 transmembrane protein. The gene is located on human chromosome 21q21.3.

Spécificité

Recognizes all types of amyloid oligomers. Appears to recognize a peptide backbone epitope that is common to amyloid oligomers, but is not found in native proteins, amyloidogenic monomer or mature amyloid fibrils.

Immunogène

Synthetic molecular mimic of soluble oligomers.

Application

Anti-APP antibody produced in rabbit has been used in western blotting.

Actions biochimiques/physiologiques

Amyloid β precursor protein (APP) regulates cell signaling. Mutation in this gene is associated with Alzheimer′s disease. It is implicated in synaptic plasticity, dendritic morphogenesis and neuroprotection. APP modulates synaptic vesicle proteins and synaptic transmission. It is involved in GABAergic transmission and maintains the excitatory/inhibitory (E/I) balance.

Amyloid precursor protein (APP) plays a key role in Wnt signalling. It helps to increase synaptoxicity, that is facilitated by Dickkopf-1 (Dkk1). Mutations on this gene results in autosomal dominant early-onset Alzheimer disease (ADEOAD)/hereditary dementia with cerebral amyloid angiopathy (CAA).

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

PBS, 50% glycerol, and 0.09% sodium azide

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable