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COO/COA

SAB4700552

Monoclonal Anti-Cd3e antibody produced in hamster

Name: Monoclonal Anti-Cd3e antibody produced in hamster
Brand: SIGMA

clone 145-2C11, purified immunoglobulin, buffered aqueous solution

Synonyme(s) :

Anti-CD3

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About This Item

Code UNSPSC :

12352203

Nomenclature NACRES :

NA.41

Source biologique

hamster

Conjugué

unconjugated

Forme d'anticorps

purified immunoglobulin

Type de produit anticorps

primary antibodies

Clone

145-2C11, monoclonal

Forme

buffered aqueous solution

Espèces réactives

mouse

Concentration

1 mg/mL

Technique(s)

flow cytometry: suitable

Isotype

IgG

Numéro d'accès NCBI

NM_007648.4

Numéro d'accès UniProt

P22646

Conditions d'expédition

wet ice

Température de stockage

2-8°C

Informations sur le gène

mouse ... Cd3e(12501)

Description générale

The hamster monoclonal antibody 145-2C11 reacts with mouse CD3 (epsilon subunit). This antibody is commonly used as a phenotypic marker for mouse T cells.

Immunogène

Mouse BM10-37 cytotoxic T lymphocytes

Application

The reagent is designed for Flow Cytometry analysis using 1-2 μg reagent / 1e6 cells in a suspension.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

12 - Non Combustible Liquids

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Lot/Batch Number

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The CD3 gamma epsilon/delta epsilon signaling module provides normal T cell functions in the absence of the TCR zeta immunoreceptor tyrosine-based activation motifs.

Lisa A Pitcher et al.

European journal of immunology, 35(12), 3643-3654 (2005-11-01)

T cell receptor (TCR) signal transduction is mediated by the immunoreceptor tyrosine-based activation motifs (ITAM). The ten ITAM in the TCR complex are distributed in two distinct signaling modules termed TCR zetazeta and CD3 gammaepsilon/deltaepsilon. To delineate the specific role

The caspase 8 inhibitor c-FLIP(L) modulates T-cell receptor-induced proliferation but not activation-induced cell death of lymphocytes.

Susanne M A Lens et al.

Molecular and cellular biology, 22(15), 5419-5433 (2002-07-09)

The caspase 8 inhibitor c-FLIP(L) can act in vitro as a molecular switch between cell death and growth signals transmitted by the death receptor Fas (CD95). To elucidate its function in vivo, transgenic mice were generated that overexpress c-FLIP(L) in

A transgenic TCR directs the development of IL-4+ and PLZF+ innate CD4 T cells.

Lingqiao Zhu et al.

Journal of immunology (Baltimore, Md. : 1950), 191(2), 737-744 (2013-06-19)

MHC class II-expressing thymocytes can efficiently mediate positive selection of CD4 T cells in mice. Thymocyte-selected CD4 (T-CD4) T cells have an innate-like phenotype similar to invariant NKT cells. To investigate the development and function of T-CD4 T cells in-depth

The Src family kinase Fyn mediates signals induced by TCR antagonists.

Qizhi Tang et al.

Journal of immunology (Baltimore, Md. : 1950), 168(9), 4480-4487 (2002-04-24)

FcR nonbinding anti-CD3 epsilon mAbs elicit partial TCR signaling that leads to T cell unresponsiveness and tolerance in vivo. In this study, the membrane-proximal events that promote T cell inactivation by FcR nonbinding anti-CD3 mAbs were examined. In the context

Killer cell lectin-like receptor G1 deficiency significantly enhances survival after Mycobacterium tuberculosis infection.

Joshua C Cyktor et al.

Infection and immunity, 81(4), 1090-1099 (2013-01-24)

The expression of T cell differentiation markers is known to increase during Mycobacterium tuberculosis infection, and yet the biological role of such markers remains unclear. We examined the requirement of the T cell differentiation marker killer cell lectin-like receptor G1

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