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SAB4504605

Sigma-Aldrich

Anti-phospho-AXL (pTyr698) antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

Anti-ARK, Anti-JTK11, Anti-Tyro7, Anti-UFO

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 97 kDa

Espèces réactives

human, mouse, rat

Concentration

~1 mg/mL

Technique(s)

ELISA: 1:20000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

Numéro d'accès NCBI

P30530

Numéro d'accès UniProt

P30530

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

phosphorylation (pTyr698)

Informations sur le gène

human ... AXL(558)

Catégories apparentées

Description générale

AXL (receptor tyrosine kinase) is also termed as Ark, UFO or Tyro7. This gene is overexpressed in pancreatic cancer tissues. AXL belongs to the receptor tyrosine kinase family. It is obtained as a transforming gene from human leukemia cells. AXL is mapped to human chromosome 19q13.

Immunogène

The antiserum was produced against synthesized peptide derived from human AXL around the phosphorylation site of Tyr691.

Immunogen Range: 657-706

Actions biochimiques/physiologiques

AXL (receptor tyrosine kinase) controls innate immune responses. It participates in cellular transformation and tumor progression. Overexpression of AXL is characterized with higher liability for lymphatic metastases.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Yanting Duan et al.
Oncology letters, 17(6), 5784-5792 (2019-06-13)
AXL receptor tyrosine kinase ligand (AXL), a tyrosine kinase receptor that is commonly overexpressed in numerous types of cancer, significantly promotes drug resistance and metastasis in tumor cells. Inhibition of the AXL/growth arrest-specific 6 (Gas6) signaling pathway is emerging as
Axl mediates ZIKA virus entry in human glial cells and modulates innate immune responses.
Meertens L, et al.
Cell Reports, 18(2), 324-333 (2017)
Victoria H Cruz et al.
JCI insight, 5 (2019-04-03)
Pancreatic ductal adenocarcinoma (PDA) is characterized by an activating mutation in KRAS. Direct inhibition of KRAS through pharmacological means remains a challenge; however, targeting key KRAS effectors has therapeutic potential. We investigated the contribution of TANK-binding kinase 1 (TBK1), a
AXL signaling in primary sensory neurons contributes to chronic compression of dorsal root ganglion-induced neuropathic pain in rats.
Lingli Liang et al.
Molecular pain, 16, 1744806919900814-1744806919900814 (2019-12-31)
Seon Min Woo et al.
International journal of molecular sciences, 20(13) (2019-07-05)
R428, a selective small molecule Axl inhibitor, is known to have anti-cancer effects, such as inhibition of invasion and proliferation and induction of cell death in cancer cells. The Axl receptor tyrosine kinase is highly expressed in cancer cells and
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