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Key Documents

SAB4500820

Sigma-Aldrich

Anti-THRB antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

Coagulation factor II, F2, THRB

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 70 kDa

Espèces réactives

human, mouse, rat

Concentration

~1 mg/mL

Technique(s)

ELISA: 1:10000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

Numéro d'accès NCBI

P00734

Numéro d'accès UniProt

P00734

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... F2(2147)

Description générale

Anti-THRB Antibody detects endogenous levels of total THRB protein.
Thyroid hormone receptor β; (THRβ) is encoded by the gene mapped to human chromosome 3p. THRβ exist in two isoforms, THRβ1 widely expressed in brain, liver and kidney and THRβ2 expressed specifically in hypothalamus and pituitary. The encoded protein contains a C- terminal ligand-binding and dimerization domain, a DNA-binding domain and a transactivation domain.

Immunogène

The antiserum was produced against synthesized peptide derived from human THRB.

Immunogen Range: 391-440

Actions biochimiques/physiologiques

Thyroid hormone receptor β (THRβ) mediates the biological functions of thyroid hormones (TH). THRβ is down-regulated in several human malignancies including papillary thyroid carcinomas (PTCs). Loss of heterozygosity in THRβ and its proximal microsatellite markers might play a crucial role in tumorigenesis and development in invasive breast cancer. Deletion of the gene coding for THRβ leads to generalized thyroid hormone resistance (GTHR). THRβ plays a vital role in the regulation of specific mRNA and miRNA in T3-induced cardiac hypertrophy and alteration of heart functions in mice.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Reduced expression of THR? in papillary thyroid carcinomas: relationship with BRAF mutation, aggressiveness and miR expression.
Rosignolo F
Journal of Endocrinological Investigation, 38, 1283-1289 (2015)
A new TR? mutation in resistance to thyroid hormone syndrome.
Neamtu C
Hormones (Athens, Greece), 15, 534-539 (2016)
Leiming Guo et al.
American journal of cancer research, 14(4), 1501-1522 (2024-05-10)
Considering the limited research and the prevailing evidence of STAT4's tumor-suppressing role in breast carcinoma (BC) or in breast radiotherapy (RT) sensitivity requires more in-depth exploration. Our study delves into how STAT4, a transcription factor, affects BC cell resistance to
Loss of heterozygosity in thyroid hormone receptor beta in invasive breast cancer.
Ling Y
Tumori, 101, 572-577 (2015)
Thyroid hormone receptor beta is essential for development of auditory function.
Nature Genetics, 13, 354-357 (1996)
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