SAB4300246

Anti-phospho-SHC1 (pTyr⁴²⁷) antibody produced in rabbit

affinity isolated antibody

• Synonyme(s) : Anti-FLJ26504 antibody produced in rabbit, Anti-SHC (Src homology 2 domain containing) transforming protein 1 antibody produced in rabbit, Anti-SHC antibody produced in rabbit, Anti-SHCA antibody produced in rabbit
• Numéro MDL: MFCD01634176
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 100
• Conjugué: unconjugated
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: buffered aqueous solution
• Poids mol.: ~46 kDa; ~52 kDa
• Espèces réactives: human
• Concentration: 1 mg/mL
• Technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; indirect immunofluorescence: 1:100-1:200; western blot: 1:500-1:1000
• Isotype: IgG
• Séquence immunogène: (P-S-YP-V-N
• Numéro d'accès NCBI: NP_001123512.1
• Numéro d'accès UniProt: P29353
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: phosphorylation (pTyr427)
• Informations sur le gène: human ... SHC1(6464)

Description

Immunogène

Peptide sequence around phosphorylation site of tyrosine 427 (P-S-Y(p)-V-N, according to the protein SHC1.

Caractéristiques et avantages

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Description de la cible

Signaling adapter that couples activated growth factor receptors to signaling pathway. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span.

Forme physique

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable