SAB4200650

Monoclonal Anti-SH3GL1 (C-terminal) antibody produced in mouse

clone Ep2.17, purified from hybridoma cell culture

• Synonyme(s) : Anti-CNSA1, Anti-EEN, Anti-SH3D2B, Anti-SH3P8
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: mouse
• Niveau de qualité: 200
• Forme d'anticorps: purified immunoglobulin
• Type de produit anticorps: primary antibodies
• Clone: Ep2.17, monoclonal
• Forme: buffered aqueous solution
• Poids mol.: ~41 kDa
• Espèces réactives: human
• Concentration: ~1 mg/mL
• Technique(s): flow cytometry: 2-5 μg/test using using HeLa cells.; immunoblotting: 1-2 μg/mL using whole extracts of HeLa.
• Isotype: IgG2b
• Numéro d'accès UniProt: Q99961
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... SH3GL1(6455)

Description

Description générale

Monoclonal Anti-SH3GL1 (C-terminal) (mouse IgG2b isotype) is derived from the hybridoma Ep2.17 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice. SH3GL1 (SH3-domain GRB2-like 1), also known as endophilin-A2, is a member of the endophilin family of Src homology 3 (SH3) domain-containing proteins. The SH3 domain drives protein-protein interactions through binding to proline-rich ligands. The SH3GL proteins have a novel N-terminal segment, and a peculiar tissue distribution: SH3GL1 is ubiquitous, SH3GL2 located in the brain, and SH3GL3 in brain and testis.

Immunogène

a synthetic peptide corresponding to a sequence at the C-terminal region of human SH3GL1

Application

Monoclonal Anti-SH3GL1 (C-terminal) antibody produced in mouse has been used in immunoblotting and flow cytometry.

Actions biochimiques/physiologiques

SH3GL1 is involved in several brain tumors, such as glioma, where its levels were increased in proportion to the tumor progression. In cells generated from children malignant brain tumor medulloblastoma (MB), SH3GL1 expression was found to be regulated by the miRNA, miR-218.

Forme physique

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable