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SAB2501420

Sigma-Aldrich

Anti-PEBP4 (C-terminal) antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

Anti-CORK-1, Anti-CORK1, Anti-GWTM1933, Anti-MGC22776, Phosphatidylethanolamine-binding protein 4

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

goat

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Espèces réactives

human

Technique(s)

immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

Numéro d'accès UniProt

Q96S96

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... PEBP4(157310)

Description générale

The gene PEBP4 (phosphatidylethanolamine binding protein 4) is mapped to human chromosome 8p21.3. It belongs to the PEBP family of proteins. The protein has potential glycosylation sites and can be secreted. It is mainly expressed in the skeletal muscle, heart and thyroid.

Immunogène

Peptide with sequence RERASEPKHKNQAE, from the C-terminal region of the protein sequence according to NP_659399.2

Actions biochimiques/physiologiques

PEBP4 (phosphatidylethanolamine binding protein 4) regulates apoptosis by associating with Raf1 (proto-oncogene serine/threonine-protein kinase) and MEK1 (MAPK/ERK kinase 1). This association blocks TNFα (tumor necrosis α) or TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) - mediated activation of MEK/ERK (extracellular signal-regulated kinase). PEBP4 is also involved in myoblast differentiation. Additionally, it promotes Akt (RAC-α serine/threonine-protein kinase) activation. The gene is expressed in various cancers and is associated with cancer progression. The PEBP4 mRNA is a target of microRNA miR-34a.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Li Chushi et al.
Gene, 587(1), 42-47 (2016-04-18)
Alteration of metabolic profile is one of the hallmarks of cancer cells. Statin, the inhibitors for synthesis of cholesterol, has shown anti-cancer effects on the gastric cancer cells. However, the functions of its target, HMGCR, in the progression of gastric
Huan He et al.
Biochimica et biophysica acta, 1863(7 Pt A), 1682-1689 (2016-04-02)
Phosphatidylethanolamine binding proteins (PEBP) represent a superfamily of proteins that are conserved from bacteria to humans. In mammals, four members have been identified, PEBP1-4. To determine the functional differences among PEBP1-4 and the underlying mechanism for their actions, we performed
Guiping Yu et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35(10), 10341-10349 (2014-07-21)
The aim of this study was to determine the relationship and underlying mechanisms between ectopic expression of phosphatidylethanolamine-binding protein 4 (PEBP4) and cisplatin (DDP)-induced cytotoxicity in the lung cancer cell line A549 to provide an experimental basis for future chemotherapeutic

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