SAB1407309

Anti-FGF21 antibody produced in mouse

purified immunoglobulin, buffered aqueous solution

• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: mouse
• Niveau de qualité: 100
• Conjugué: unconjugated
• Forme d'anticorps: purified immunoglobulin
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: buffered aqueous solution
• Poids mol.: antigen ~22.3 kDa
• Espèces réactives: human, rat
• Technique(s): western blot: 1 μg/mL
• Numéro d'accès NCBI: BC018404
• Numéro d'accès UniProt: Q9NSA1
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... FGF21(26291)

Description

Description générale

FGF (fibroblast growth factor) family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this growth factor has not yet been determined. The gene is mapped to human chromosome 19q13.33 and codes for a member of FGF superfamily. The encoded protein is produced in liver.

Immunogène

FGF21 (AAH18404.1, 1 a.a. ~ 209 a.a) full-length human protein.

Sequence
MDSDETGFEHSGLWVSVLAGLLLGACQAHPIPDSSPLLQFGGQVRQRYLYTDDAQQTEAHLEIREDGTVGGAADQSPESLLQLKALKPGVIQILGVKTSRFLCQRPDGALYGSLHFDPEACSFRELLLEDGYNVYQSEAHGLPLHLPGNKSPHRDPAPRGPARFLPLPGLPPAPPEPPGILAPQPPDVGSSDPLSMVGPSQGRSPSYAS

Actions biochimiques/physiologiques

The members of FGF (fibroblast growth factor) family take part in cell survival and mitogenic activities. FGFs are associated with a number of physiological processes such as cell growth, morphogenesis, embryonic development, tissue repair, tumor growth and invasion. FGF21 is a hormonal factor that regulates glucose homeostasis and energy metabolism. It possesses anti-diabetic properties by mediating glucose uptake in peripheral tissues. It also exhibits autocrine effects in white adipose tissue. FGF21 is present in milk and is needed for intestinal function in the neonate. It is also associated with bone loss. FGF21 is considered hepatoprotective in nature.

Forme physique

Solution in phosphate buffered saline, pH 7.4

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable