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COO/COA

SAB1401100

Anti-CYC1 antibody produced in rabbit

Name: Anti-CYC1 antibody produced in rabbit
Brand: SIGMA

purified immunoglobulin, buffered aqueous solution

Synonyme(s) :

UQCR4

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About This Item

Code UNSPSC :

12352203

Nomenclature NACRES :

NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

purified immunoglobulin

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Espèces réactives

mouse, human

Technique(s)

western blot: 1 μg/mL

Numéro d'accès NCBI

NM_001916

Numéro d'accès UniProt

P08574

Conditions d'expédition

dry ice

Température de stockage

−20°C

Informations sur le gène

human ... CYC1(1537)

Description générale

Cytochrome c1 (CYC1) is a heme-containing constituent of mitochondrial complex III. It is encoded by the gene mapped to human chromosome 8q24.3. The encoded protein is attached to the phospholipid bilayer by a single C-proximal transmembrane segment.

Immunogène

CYC1 (NP_001907.2, 1 a.a. ~ 325 a.a) full-length human protein.

Sequence
MAAAAASLRGVVLGPRGAGLPGARARGLLCSARPGQLPLRTPQAVALSSKSGLSRGRKVMLSALGMLAAGGAGLAVALHSAVSASDLELHPPSYPWSHRGLLSSLDHTSIRRGFQVYKQVCASCHSMDFVAYRHLVGVCYTEDEAKELAAEVEVQDGPNEDGEMFMRPGKLFDYFPKPYPNSEAARAANNGALPPDLSYIVRARHGGEDYVFSLLTGYCEPPTGVSLREGLYFNPYFPGQAIAMAPPIYTDVLEFDDGTPATMSQIAKDVCTFLRWASEPEHDHRKRMGLKMLMMMALLVPLVYTIKRHKWSVLKSRKLAYRPPK

Actions biochimiques/physiologiques

Cytochrome c1 (CYC1) stimulates oxidative phosphorylation activity in human ductal carcinoma in- situ (DCIS) and thus, plays an essential role in cell proliferation and comedo necrosis. CYC1 expression is implicated in breast cancer progression and might act as a predictive factor for poor prognosis in breast cancer patients. Variation in the gene expression leads to mitochondrial complex III deficiency.

Forme physique

Solution in phosphate buffered saline, pH 7.4

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Assignment of the gene for the cytochrome c1 subunit of the mitochondrial cytochrome bc1 complex (CYC1) to human chromosome 8q24.3.

Duncan AM, et al.

Genomics, 400-401 (1994)

Cytochrome c1 in ductal carcinoma in situ of breast associated with proliferation and comedo necrosis.

Chishiki M, et al.

Cancer Science, 108(7), 1510-1519 (2017)

CYC1 Predicts Poor Prognosis in Patients with Breast Cancer

Han Y, et al.

Disease Markers (2016)

Mutations in CYC1, encoding cytochrome c1 subunit of respiratory chain complex III, cause insulin-responsive hyperglycemia.

Pauline Gaignard et al.

American journal of human genetics, 93(2), 384-389 (2013-08-06)

Many individuals with abnormalities of mitochondrial respiratory chain complex III remain genetically undefined. Here, we report mutations (c.288G>T [p.Trp96Cys] and c.643C>T [p.Leu215Phe]) in CYC1, encoding the cytochrome c1 subunit of complex III, in two unrelated children presenting with recurrent episodes

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