The NUPR1 (nuclear protein 1, transcriptional regulator) gene is mapped to human chromosome 16p11.2 and encodes a chromatin remodeling protein of 8.8 KDa.
Immunogène
synthetic peptide corresponding to amino acids 47-60 of human NUPR1
Application
Anti-NUPR1 (47-60) antibody produced in rabbit has been used in western blot analysis.
Actions biochimiques/physiologiques
Nupr1 (nuclear protein 1, transcriptional regulator) is a stress response factor, induced by lipopolysaccharides, CCl4, starvation, cell cycle arrest and other protein stimuli. NUPR1 is associated with tumor cell proliferation, metastasis and apoptosis, also regulates entosis, matrix remodeling and autophagy. It serves as a substrate for protein kinase A. Overexpression of this gene is observed in glioblastoma and hepatocellular carcinoma. The protein function is tissue specific and differs at molecular level. It can act as a tumor suppressor or inducer.
Forme physique
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
12 - Non Combustible Liquids
Classe de danger pour l'eau (WGK)
WGK 2
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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The Journal of Clinical Investigation, 126(9), 3263-3278 (2016)
Pivotal role of the chromatin protein Nupr1 in Kras-induced senescence and transformation.
Grasso D, et al.
Scientific Reports, 5, 17549-17549 (2015)
Hexavalent chromium (Cr (VI)) down-regulates acetylation of histone H4 at lysine 16 through induction of stressor protein Nupr1.
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